Unveiled an essential mechanism in embryonic development: the key role of the number of DNA copies

Researchers from the CSIC’s Institute of Molecular Biology of Barcelona and IRB Barcelona reveal how the number of copies of genetic material influences the cell death processes that shape organs during development. The autophagy process, related to the recycling of cellular components and cell death, plays a fundamental role in the stress response and in cancer. The work has been published in the journal Autophagy.

Reference article:
Polyploidy-associated autophagy promotes larval tracheal histolysis at Drosophila metamorphosis. Beatriz Pino-Jiménez, Panagiotis Giannios & Jordi Casanova. Autophagy (2022) DOI: 10.1080/15548627.2023.2231828

Source of information:
https://delegacion.catalunya.csic.es/desvelado-un-mecanismo-esencial-en-el-desarrollo-embrionario-el-papel-clave-del-numero-de-copias-del-adn/