Lab presentation
Structural Biology of Oxidative Stress Systems. From Organelles to Membrane Proteins
The major expertise of the lab is in Macromolecular X-Ray Crystallography. Currently we are especially interested in studies requiring the integration of different structural methodologies with research centered on two biological systems, one prokaryotic and one eukaryotic:
- The Functional and Structural Study of Mycoplasmas Terminal Organelle
- The Structure and Interactions of Peroxisomal Proteins
Several targets of our research lines include macromolecular aggregates and membrane-associated or integral membrane proteins. In addition, we also have a number of different collaborative projects mainly related with oxidative-stress processes and pathologies.
Projects
there is currently no project published on this page
Lab people

Ignacio Fita Rodriguez

Alicia Guasch Mitjans

Rosa Perez Luque

David Vizarraga Revuelto

Jesús Martín Romero
Past Students
Selected publications
Essential protein P116 extracts cholesterol and other indispensable lipids for Mycoplasmas
D. Vizarraga*& L. Sprankel* et al. I. Fita# & A. Frangakis#
Nature Structural & Molecular biology (2023)
L amino acid transporter structure and molecular bases for the asymmetry of substrate interaction.
Errasti-Murugarren E, Fort J, Bartoccioni P, Díaz L, Pardon E, Carpena X, Espino-Guarch M, Zorzano A, Ziegler C, Steyaert J, Fernández-Recio J, Fita I, Palacín M.
Nat Commun. 2019 Apr 18;10(1):1807.
Mycoplasma genitalium adhesin P110 binds sialic-acid human receptors.
Aparicio D, Torres-Puig S, Ratera M, Querol E, Piñol J, Pich OQ, Fita I.
Nat Commun. 2018 Oct 26;9(1):4471.
Aparicio D, Pérez-Luque R, Carpena X, Díaz M, Ferrer JC, Loewen PC, Fita I
J Biol Chem 288: 11907-11919. (2013)
Garreta A, Val-Moraes SP, García-Fernández Q, Busquets M, Juan C, Oliver A, Ortiz A, Gaffney BJ, Fita I, Manresa A, Carpena X
FASEB J 27(12):4811-21. (2013)
The EAGR box structure: a motif involved in mycoplasma motility.
Calisto BM, Broto A, Martinelli L, Querol E, Piñol J, Fita I
Mol Microbiol 86: 382-393. (2012)
Pérez-Gil J, Calisto BM, Behrendt C, Kurz T, Fita I, Rodríguez-Concepción M
J Biol Chem 287: 15803-15809. (2012)
Zámocký M, García-Fernández Q, Gasselhuber B, Jakopitsch C, Furtmüller PG, Loewen PC, Fita I, Obinger C, Carpena X
J Biol Chem 287: 32254-32262. (2012)
Molecular basis of substrate-induced permeation by an amino acid antiporter.
Kowalczyk L, Ratera M, Paladino A, Bartoccioni P, Errasti-Murugarren E, Valencia E, Portella G, Bial S, Zorzano A, Fita I, Orozco M, Carpena X, Vázquez-Ibar JL, Palacín M
Proc Natl Acad Sci USA 108: 3935-3940. (2011)
Isonicotinic acid hydrazide conversion to Isonicotinyl-NAD by catalase-peroxidases.
Wiseman B, Carpena X, Feliz M, Donald LJ, Pons M, Fita I, Loewen PC
J Biol Chem 285: 26662-26673. (2010)
The mechanism of vault opening from the high resolution structure of the N-terminal repeats of MVP.
Querol-Audí J, Casañas A, Usón I, Luque D, Castón JR, Fita I, Verdaguer N
EMBO J 28: 3450-3457. (2009)
Essential role of proximal histidine-asparagine interaction in mammalian peroxidases.
Carpena X, Vidossich P, Schroettner K, Calisto BM, Banerjee S, Stampler J, Soudi M, Furtmüller PG, Rovira C, Fita I, Obinger C
J Biol Chem 284: 25929-25937. (2009)
Alfonso-Prieto M, Borovik A, Carpena X, Murshudov G, Melik-Adamyan W, Fita I, Rovira C, Loewen PC
J Am Chem Soc 129: 4193-4205. (2007)
Gallego O, Ruiz FX, Ardèvol A, Domínguez M, Alvarez R, de Lera AR, Rovira C, Farrés J, Fita I, Parés X
Proc Natl Acad Sci USA 104: 20764-20769. (2007)
Llàcer JL, Contreras A, Forchhammer K, Marco-Marín C, Gil-Ortiz F, Maldonado R, Fita I, Rubio V
Proc Natl Acad Sci USA 104: 17644-17649. (2007)
All publications
Essential protein P116 extracts cholesterol and other indispensable lipids for Mycoplasmas
D. Vizarraga*& L. Sprankel* et al. I. Fita# & A. Frangakis#
Nature Structural & Molecular biology (2023)
L amino acid transporter structure and molecular bases for the asymmetry of substrate interaction.
Errasti-Murugarren E, Fort J, Bartoccioni P, Díaz L, Pardon E, Carpena X, Espino-Guarch M, Zorzano A, Ziegler C, Steyaert J, Fernández-Recio J, Fita I, Palacín M.
Nat Commun. 2019 Apr 18;10(1):1807.
Cis-trans proline isomers in the catalytic domain of calcineurin.
Teixeira JMC, Guasch A, Biçer A, Aranguren-Ibáñez Á, Chashmniam S, Paniagua JC, Pérez-Riba M, Fita I, Pons M.
FEBS J. 2019 Mar;286(6):1230-1239.
Mycoplasma genitalium adhesin P110 binds sialic-acid human receptors.
Aparicio D, Torres-Puig S, Ratera M, Querol E, Piñol J, Pich OQ, Fita I.
Nat Commun. 2018 Oct 26;9(1):4471.
The nucleotide-bound/substrate-bound conformation of the Mycoplasma genitalium DnaK chaperone.
Adell M., Calisto B.M., Fita I., Martinelli L.
Protein Sci. 2018 May;27(5):1000-1007.
KatG-Mediated Oxidation Leading to Reduced Susceptibility of Bacteria to Kanamycin.
Loewen P.C., De Silva P.M., Donald L.J., Switala J., Villanueva J., Fita I., Kumar A.
ACS Omega. 2018 Apr 30;3(4):4213-4219.
Gordo V., Aparicio D., Pérez-Luque R., Benito A., Vilanova M., Usón I., Fita I., Ribó M.
Cell Chem Biol. 2018 Apr 25. pii: S2451-9456(18)30122-3.
Wang B., Fita I., Rovira C.
Chemistry. 2018 Apr 6;24(20):5388-5395.
Prediction of Protein Configurational Entropy (Popcoen).
Goethe M, Gleixner J, Fita I, Rubi JM.
J Chem Theory Comput. 2018 Mar 13;14(3):1811-1819.
Testing the mutual information expansion of entropy with multivariate Gaussian distributions.
Goethe M., Fita I., Rubi J.M.
J Chem Phys. 2017 Dec 14;147(22):224102.8
Scheffer MP, Gonzalez-Gonzalez L, Seybert A, Ratera M, Kunz M, Valpuesta JM, Fita I, Querol E, Piñol J, Martín-Benito J, Frangakis AS.
Mol Microbiol. 2017 Sep;105(6):869-879.
Machuqueiro M, Victor B, Switala J, Villanueva J, Rovira C, Fita I, Loewen PC.
Biochemistry. 2017 May 2;56(17):2271-2281
Díaz-Lobo M, Concia AL, Gómez L, Clapés P, Fita I, Guinovart JJ, Ferrer JC.
Org Biomol Chem. 2016 Sep 26;14(38):9105-9113.
Thermal motions in protein: Large effects on the time-averaged interaction energies
M Goethe, I Fita, JM Rubi.
AIP Advances 6, 035020. (2016)
Martinelli L, García-Morales L, Querol E, Piñol J, Fita I, Calisto BM.
PLoS Pathog. 12(4):e1005533. (2016)
de Cima S, Polo LM, Díez-Fernández C, Martínez AI, Cervera J, Fita I, Rubio V.
Sci. Rep. 5, 1695. (2015)
Díaz-Lobo M, Garcia-Amorós J, Fita I, Velasco D, Guinovart JJ, Ferrer JC.
Org Biomol Chem. 13(26):7282-8. (2015)
Catalase-Peroxidase (KatG) structure and function.
I. Fita, X. Carpena, P. C. Loewen
In Heme Peroxidases, 133-155 (Royal Society of Chemistry Publishing). Ed. B. Dunford. (2015)
Fita, I., Loewen, P. C. and Carpena, X.
Encyclopedia of Inorganic and Bioinorganic Chemistry. 1–14. (2015)
Gasselhuber B, Carpena X, Graf MM, Pirker KF, Nicolussi A, Sündermann A, Hofbauer S, Zamocky M, Furtmüller PG, Jakopitsch C, Oostenbrink C, Fita I, Obinger C.
Biochemistry 54(35):5425-38. (2015)
Vibrational entropy of a protein: large differences between distinct conformations.
Goethe M, Fita I, Rubi JM.
J Chem Theory Comput 11(1):351-9.(2015)
Calcineurin undergoes a conformational switch evoked via peptidylprolyl isomerization.
A. Guasch, A. Aranguren-Ibáñez, R. Pérez-Luque, D. Aparicio, S. Martínez-Høyer, M. C. Mulero, E. Serrano-Candelas, M. Pérez-Riba ,I. Fita
PLos One, e0134569. (2015).
L Martinelli, D Lalli, L Garćia-Morales, M Ratera, E Querol, J Piñol, I Fita, B. M. Calisto.
Journal of Biological Chemistry, M114. 594762 (2015)
An Ionizable Active-Site Tryptophan imparts Catalase Activity to a Peroxidase Core.
P. C. Loewen, X. Carpena, P. Vidossich, I. Fita, C. Rovira.
Journal of the American Chemical Society 136, 7249-52. (2014)
P. Vidossich, P. C. Loewen, X. Carpena, G. Fiorin, I. Fita, C. Rovira
J. Phys. Chem. B 20, 2924-31. (2014)
Aparicio D, Pérez-Luque R, Carpena X, Díaz M, Ferrer JC, Loewen PC, Fita I
J Biol Chem 288: 11907-11919. (2013)
Casañas A, Querol-Audí J, Guerra P, Pous J, Tanaka H, Tsukihara T, Verdaguer N, Fita I
Acta Crystallogr D Biol Crystallogr 69: 1054-1061. (2013)
Garreta A, Val-Moraes SP, García-Fernández Q, Busquets M, Juan C, Oliver A, Ortiz A, Gaffney BJ, Fita I, Manresa A, Carpena X
FASEB J 27(12): 4811–4821 (2013)
Ivancich A, Donald LJ, Villanueva J, Wiseman B, Fita I, Loewen PC
Biochemistry 52: 7271-7282. (2013)
Structure of Pisum sativum Rubisco with bound ribulose 1,5-bisphosphate.
Loewen PC, Didychuk AL, Switala J, Perez-Luque R, Fita I, Loewen MC
Acta Crystallogr Sect F Struct Biol Cryst Commun 69: 10-14. (2013)
X-ray crystallography of viruses.
Verdaguer N, Garriga D, Fita I
Subcell Biochem 68: 117-144. (2013)
Alarcon DA, Nandi M, Carpena X, Fita I, Loewen PC
Acta Crystallogr Sect F Struct Biol Cryst Commun 68: 1279-1283. (2012)
The EAGR box structure: a motif involved in mycoplasma motility.
Calisto BM, Broto A, Martinelli L, Querol E, Piñol J, Fita I
Mol Microbiol 86: 382-393. (2012)
Vault particles: a new generation of delivery nanodevices.
Casañas A, Guerra P, Fita I, Verdaguer N
Curr Opin Biotechnol 23: 972-977. (2012)
Thirty years of heme catalases structural biology.
Díaz A, Loewen PC, Fita I, Carpena X
Arch Biochem Biophys 525: 102-110. (2012)
Jha V, Chelikani P, Carpena X, Fita I, Loewen PC
Arch Biochem Biophys 526: 54-59. (2012)
Pérez-Gil J, Calisto BM, Behrendt C, Kurz T, Fita I, Rodríguez-Concepción M
J Biol Chem 287: 15803-15809. (2012)
Zámocký M, García-Fernández Q, Gasselhuber B, Jakopitsch C, Furtmüller PG, Loewen PC, Fita I, Obinger C, Carpena X
J Biol Chem 287: 32254-32262. (2012)
de Cima S, Gil-Ortiz F, Crabeel M, Fita I, Rubio V
PLoS One 7: e34734. (2011)
Re-engineering specificity in 1,3-1, 4-β-glucanase to accept branched xyloglucan substrates.
Addington T, Calisto B, Alfonso-Prieto M, Rovira C, Fita I, Planas A (2011)
Proteins 79: 365-375. (2011)
Díaz A, Martínez-Pons C, Fita I, Ferrer JC, Guinovart JJ
J Biol Chem 286: 18505-18514. (2011)
Modulation of heme orientation and binding by a single residue in catalase HPII of Escherichia coli.
Jha V, Louis S, Chelikani P, Carpena X, Donald LJ, Fita I, Loewen PC (2011)
Biochemistry 50: 2101-2110. (2011)
Molecular basis of substrate-induced permeation by an amino acid antiporter.
Kowalczyk L, Ratera M, Paladino A, Bartoccioni P, Errasti-Murugarren E, Valencia E, Portella G, Bial S, Zorzano A, Fita I, Orozco M, Carpena X, Vázquez-Ibar JL, Palacín M
Proc Natl Acad Sci U S A 108: 3935-3940. (2011)
Gil-Ortiz F, Ramón-Maiques S, Fernández-Murga ML, Fita I, Rubio V
J Mol Biol 399: 476-490. (2010)
Ramón-Maiques S, Marina A, Guinot A, Gil-Ortiz F, Uriarte M, Fita I, Rubio V
J Mol Biol 397: 1261-1275. (2010)
Vidossich P, Alfonso-Prieto M, Carpena X, Fita I, Loewen PC, Rovira C
Arch Biochem Biophys 500: 37-44. (2010)
Isonicotinic acid hydrazide conversion to Isonicotinyl-NAD by catalase-peroxidases.
Wiseman B, Carpena X, Feliz M, Donald LJ, Pons M, Fita I, Loewen PC
J Biol Chem 285: 26662-26673. (2010)
Essential role of proximal histidine-asparagine interaction in mammalian peroxidases.
Carpena X, Vidossich P, Schroettner K, Calisto BM, Banerjee S, Stampler J, Soudi M, Furtmüller PG, Rovira C, Fita I, Obinger C
J Biol Chem 284: 25929-25937. (2009)
Structural and mechanistic insights into the association of PKCalpha-C2 domain to PtdIns(4,5)P2.
Guerrero-Valero M, Ferrer-Orta C, Querol-Audí J, Marin-Vicente C, Fita I, Gómez-Fernández JC, Verdaguer N, Corbalán-García S
Proc Natl Acad Sci U S A 106: 6603-6607. (2009)
Porté S, Valencia E, Yakovtseva EA, Borrás E, Shafqat N, Debreczeny JE, Pike ACW, Oppermann U, Farrés J, Fita I, Parés X
J Biol Chem 284: 17194-17205. (2009)
The mechanism of vault opening from the high resolution structure of the N-terminal repeats of MVP.
Querol-Audí J, Casañas A, Usón I, Luque D, Castón JR, Fita I, Verdaguer N
EMBO J 28: 3450-3457. (2009)
Querol-Audí J, Konecsni T, Pous J, Carugo O, Fita I, Verdaguer N, Blaas D
FEBS Lett 583: 235-240. (2009)
Ruiz FX, Gallego O, Ardèvol A, Moro A, Domínguez M, Alvarez S, Alvarez R, de Lera AR, Rovira C, Fita I, Parés X, Farrés J
Chem Biol Interact 178: 171-177. (2009)
Electronic state of the molecular oxygen released by catalase.
Alfonso-Prieto M, Vidossich P, Rodríguez-Fortea A, Carpena X, Fita I, Loewen PC, Rovira C
J Phys Chem A 112: 12842-12848. (2008)
Brucet M, Querol-Audí J, Bertlik K, Lloberas J, Fita I, Celada A
Protein Sci 17: 2059-2069. (2008)
Arginine and nitrogen storage.
Llàcer JL, Fita I, Rubio V
Curr Opin Struct Biol 18: 673-681. (2008)
Alfonso-Prieto M, Borovik A, Carpena X, Murshudov G, Melik-Adamyan W, Fita I, Rovira C, Loewen PC
J Am Chem Soc 129: 4193-4205. (2007)
Brucet M, Querol-Audí J, Serra M, Ramirez-Espain X, Bertlik K, Ruiz L, Lloberas J, Macias MJ, Fita I, Celada A
J Biol Chem 282: 14547-14557. (2007)
Calisto BM, Perez-Gil J, Bergua M, Querol-Audi J, Fita I, Imperial S
Protein Sci 16: 2082-2088. (2007)
Deemagarn T, Wiseman B, Carpena X, Ivancich A, Fita I, Loewen PC
Proteins 66: 219-228. (2007)
Fort J, de la Ballina LR, Burghardt HE, Ferrer-Costa C, Turnay J, Ferrer-Orta C, Usón I, Zorzano A, Fernández-Recio J, Orozco M, Lizarbe MA, Fita I, Palacín M
J Biol Chem 282: 31444-31452. (2007)
Gallego O, Ruiz FX, Ardèvol A, Domínguez M, Alvarez R, de Lera AR, Rovira C, Farrés J, Fita I, Parés X
Proc Natl Acad Sci U S A 104: 20764-20769. (2007)
Llàcer JL, Contreras A, Forchhammer K, Marco-Marín C, Gil-Ortiz F, Maldonado R, Fita I, Rubio V
Proc Natl Acad Sci U S A 104: 17644-17649. (2007)
Marco-Marín C, Gil-Ortiz F, Pérez-Arellano I, Cervera J, Fita I, Rubio V
J Mol Biol 367: 1431-1446. (2007)
Versatility of the electronic structure of compound I in catalase-peroxidases.
Vidossich P, Alfonso-Prieto M, Carpena X, Loewen PC, Fita I, Rovira C
J Am Chem Soc 129: 13436-13446. (2007)
Carpena X, Wiseman B, Deemagarn T, Herguedas B, Ivancich A, Singh R, Loewen PC, Fita I
Biochemistry 45: 5171-5179. (2006)
Horcajada C, Guinovart JJ, Fita I, Ferrer JC
J Biol Chem 281: 2923-2931. (2006).
Ramón-Maiques S, Fernández-Murga ML, Gil-Ortiz F, Vagin A, Fita I, Rubio V
J Mol Biol 356: 695-713. (2006)
Trapani S, Abergel C, Gutsche I, Horcajada C, Fita I, Navaza J
Acta Crystallogr D Biol Crystallogr 62: 467-475. (2006)
Calisto BM, Pich OQ, Piñol J, Fita I, Querol E, Carpena X
J Mol Biol 351: 749-762. (2005)
A molecular switch and electronic circuit modulate catalase activity in catalase-peroxidases.
Carpena X, Wiseman B, Deemagarn T, Singh R, Switala J, Ivancich A, Fita I, Loewen PC
EMBO Rep 6: 1156-1162. (2005)
Characterization of a large subunit catalase truncated by proteolytic cleavage.
Chelikani P, Carpena X, Perez-Luque R, Donald LJ, Duckworth HW, Switala J, Fita I, Loewen PC
Biochemistry 44: 5597-5605. (2005)
Deemagarn T, Carpena X, Singh R, Wiseman B, Fita I, Loewen PC
J Mol Biol 345: 21-28. (2005)
Preliminary analysis of two and three dimensional crystals of vault ribonucleoprotein particles.
Querol-Audí J, Perez-Luque R, Fita I, Lopez-Iglesias C, Castón JR, Carrascosa JL, Verdaguer N
J Struct Biol 151: 111-115. (2005)
Structure of the C-terminal domain of the catalase-peroxidase KatG from Escherichia coli.
Carpena X, Melik-Adamyan W, Loewen PC, Fita I
Acta Crystallogr F 60: 1824-1832. (2004)
Diversity of structures and properties among catalases.
Chelikani P, Fita I, Loewen PC
Cell Mol Life Sci 61: 192-208. (2004)
Structure of Helicobacter pylori catalase, with and without formic acid bound, at 1.6 A resolution.
Loewen PC, Carpena X, Rovira C, Ivancich A, Perez-Luque R, Haas R, Odenbreit S, Nicholls P, Fita I
Biochemistry 43: 3089-3103. (2004)
Catalase-peroxidases (KatG) exhibit NADH oxidase activity.
Singh R, Wiseman B, Deemagarn T, Donald LJ, Duckworth HW, Carpena X, Fita I, Loewen PC
J Biol Chem 279: 43098-43106. (2004)
Valencia E, Larroy C, Ochoa WF, Parés X, Fita I, Biosca JA
J Mol Biol 341: 1049-1062. (2004)
Verdaguer N, Fita I, Reithmayer M, Moser R, Blaas D
Nat Struct Mol Biol 11: 429-434. (2004)
Catalase-peroxidase KatG of Burkholderia pseudomallei at 1.7A resolution.
Carpena X, Loprasert S, Mongkolsuk S, Switala J, Loewen PC, Fita I
J Mol Biol 327: 475-489. (2003)
Structure of the Clade 1 catalase, CatF of Pseudomonas syringae, at 1.8 A resolution
Carpena X, Soriano M, Klotz MG, Duckworth HW, Donald LJ, Melik-Adamyan W, Fita I, Loewen PC
Proteins 50: 423-436. (2003)
An electrical potential in the access channel of catalases enhances catalysis.
Chelikani P, Carpena X, Fita I, Loewen PC
J Biol Chem 278: 31290-31296. (2003)
Donald LJ, Krokhin OV, Duckworth HW, Wiseman B, Deemagarn T, Singh R, Switala J, Carpena X, Fita I, Loewen PC
J Biol Chem 278: 35687-35692. (2003)
Gil-Ortiz F, Ramón-Maiques S, Fita I, Rubio V
J Mol Biol 331: 231-244. (2003)
Crystallization and preliminary X-ray analysis of swine vesicular disease virus (SVDV).
Jimenez-Clavero MA, Ley V, Fita I, Verdaguer N
Acta Crystallogr D Biol Crystallogr 59: 541-543. (2003)
Retinoic acid binds to the C2-domain of protein kinase C(alpha).
Ochoa WF, Torrecillas A, Fita I, Verdaguer N, Corbalán-García S, Gomez-Fernandez JC
Biochemistry 42: 8774-8779. (2003)
Rosell A, Valencia E, Ochoa WF, Fita I, Parés X, Farrés J
J Biol Chem 278: 40573-40580. (2003)
Crystal structure of the vertebrate NADP(H)-dependent alcohol dehydrogenase (ADH8).
Rosell A, Valencia E, Parés X, Fita I, Farrés J, Ochoa WF
J Mol Biol 330: 75-85. (2003)
Valencia E, Rosell A, Larroy C, Farrés J, Biosca JA, Fita I, Parés X, Ochoa WF
Acta Crystallogr D Biol Crystallogr 59: 334-337. (2003)
Verdaguer N, Jimenez-Clavero MA, Fita I, Ley V
J Virol 77: 9780-9789. (2003)
Carpena X, Guarné A, Ferrer JC, Alzari PM, Fita I, Loewen PC
Acta Crystallogr D Biol Crystallogr 58: 853-855. (2002)
Carpena X, Switala J, Loprasert S, Mongkolsuk S, Fita I, Loewen PC
Acta Crystallogr D Biol Crystallogr 58: 2184-2186. (2002)
Fernández-Murga ML, Ramón-Maiques S, Gil-Ortiz F, Fita I, Rubio V
Acta Crystallogr D Biol Crystallogr 58: 1045-1047. (2002)
Gil-Ortiz F, Fita I, Ramón-Maiques S, Marina A, Rubio V
Acta Crystallogr D Biol Crystallogr 58: 1892-1895. (2002)
Ochoa WF, Corbalán-Garcia S, Eritja R, Rodríguez-Alfaro JA, Gómez-Fernández JC, Fita I, Verdaguer N
J Mol Biol 320: 277-291. (2002)
Ramón-Maiques S, Marina A, Gil-Ortiz F, Fita I, Rubio V
Structure 10: 329-342. (2002)
Carpena X, Perez R, Ochoa WF, Verdaguer N, Klotz MG, Switala J, Melik-Adamyan W, Fita I, Loewen PC
Acta Crystallogr D Biol Crystallogr 57: 1184-1186. (2001)
Theoretical study of the mechanisms of substrate recognition by catalase.
Kalko SG, Gelpí JL, Fita I, Orozco M
J Am Chem Soc 123: 9665-9672. (2001)
Melik-Adamyan W, Bravo J, Carpena X, Switala J, Maté MJ, Fita I, Loewen PC
Proteins 44: 270-281. (2001)
Ochoa WF, Garcia-Garcia J, Fita I, Corbalan-Garcia S, Verdaguer N, Gomez-Fernandez JC
J Mol Biol 311: 837-849. (2001)
Guarné A, Hampoelz B, Glaser W, Carpena X, Tormo J, Fita I, Skern T
J Mol Biol 302: 1227-1240. (2000)
Kalko SG, Chagoyen M, Jiménez-Lozano N, Verdaguer N, Fita I, Carazo JM
Eur Biophys J 29: 457-462. (2000)
Ochoa WF, Kalko SG, Mateu MG, Gomes P, Andreu D, Domingo E, Fita I, Verdaguer N
J Gen Virol 81: 1495-1505. (2000)
Ramón-Maiques S, Marina A, Uriarte M, Fita I, Rubio V
J Mol Biol 299: 463-476. (2000)
Structure of human rhinovirus serotype 2 (HRV2).
Verdaguer N, Blaas D, Fita I
J Mol Biol 300: 1179-1194. (2000)
Structure of catalase HPII from Escherichia coli at 1.9 A resolution.
Bravo J, Mate MJ, Schneider T, Switala J, Wilson K, Loewen PC, Fita I
Proteins 34: 155-166. (1999)
Organising multi-dimensional biological image information: the BioImage Database.
Carazo JM, Stelzer EH, Engel A, Fita I, Henn C, Machtynger J, McNeil P, Shotton DM, Chagoyen M, de Alarcón PA, Fritsch R, Heymann JB, Kalko S, Pittet JJ, Rodriguez-Tomé P, Boudier T
Nucleic Acids Res 27: 280-283. (1999)
Domingo E, Verdaguer N, Ochoa WF, Ruiz-Jarabo CM, Sevilla N, Baranowski E, Mateu MG, Fita I
Virus Res 62: 169-175. (1999)
Gil F, Ramón-Maiques S, Marina A, Fita I, Rubio V
Acta Crystallogr D Biol Crystallogr 55: 1350-1352. (1999)
Marina A, Alzari PM, Bravo J, Uriarte M, Barcelona B, Fita I, Rubio V
Protein Sci 8: 934-940. (1999)
Crystallization and preliminary structural results of catalase from human erythrocytes.
Maté MJ, Ortiz-Lombardía M, Marina A, Fita I
Acta Crystallogr D Biol Crystallogr 55: 1066-1068. (1999)
Mutants that alter the covalent structure of catalase hydroperoxidase II from Escherichia coli.
Maté MJ, Sevinc MS, Hu B, Bujons J, Bravo J, Switala J, Ens W, Loewen PC, Fita I
J Biol Chem 274: 27717-27725. (1999)
Structure of catalase-A from Saccharomyces cerevisiae.
Maté MJ, Zamocky M, Nykyri LM, Herzog C, Alzari PM, Betzel C, Koller F, Fita I
J Mol Biol 286: 135-149. (1999)
The structures of picornaviral proteinases.
Seipelt J, Guarné A, Bergmann E, James M, Sommergruber W, Fita I, Skern T
Virus Res 62: 159-168. (1999)
Role of the lateral channel in catalase HPII of Escherichia coli.
Sevinc MS, Maté MJ, Switala J, Fita I, Loewen PC
Protein Sci 8: 490-498. (1999)
Uriarte M, Marina A, Ramón-Maiques S, Fita I, Rubio V
J Biol Chem 274: 16295-16303. (1999)
Verdaguer N, Corbalan-Garcia S, Ochoa WF, Fita I, Gómez-Fernández JC
EMBO J 18: 6329-6338. (1999)
Crystallization and preliminary X-ray analysis of human rhinovirus serotype 2 (HRV2).
Verdaguer N, Marlovits TC, Bravo J, Stuart DI, Blaas D, Fita I
Acta Crystallogr D Biol Crystallogr 55: 1459-1461. (1999)
Verdaguer N, Schoehn G, Ochoa WF, Fita I, Brookes S, King A, Domingo E, Mateu MG, Stuart D, Hewat EA
Virology 255: 260-268. (1999)
Guarné A, Tormo J, Kirchweger R, Pfistermueller D, Fita I, Skern T
EMBO J 17: 7469-7479. (1998)
Molins MA, Contreras MA, Fita I, Pons M
J Pept Sci 4: 101-110. (1998)
Sevinc MS, Switala J, Bravo J, Fita I, Loewen PC
Protein Eng 11: 549-555. (1998)
A structural model of picornavirus leader proteinases based on papain and bleomycin hydrolase.
Skern T, Fita I, Guarné A
J Gen Virol 79 (Pt 2): 301-307. (1998)
Verdaguer N, Sevilla N, Valero ML, Stuart D, Brocchi E, Andreu D, Giralt E, Domingo E, Mateu MG, Fita I
J Virol 72: 739-748. (1998)
Crystallization and preliminary structural analysis of catalase A from Saccharomyces cerevisiae.
Berthet S, Nykyri LM, Bravo J, Mate MJ, Berthet-Colominas C, Alzari PM, Koller F, Fita I
Protein Sci 6: 481-483. (1997)
Bravo J, Fita I, Ferrer JC, Ens W, Hillar A, Switala J, Loewen PC
Protein Sci 6: 1016-1023. (1997)
Hewat EA, Verdaguer N, Fita I, Blakemore W, Brookes S, King A, Newman J, Domingo E, Mateu MG, Stuart DI
EMBO J 16: 1492-1500. (1997)
Kumar A, Reddy VS, Yusibov V, Chipman PR, Hata Y, Fita I, Fukuyama K, Rossmann MG, Loesch-Fries LS, Baker TS, Johnson JE
J Virol 71: 7911-7916. (1997)
Efficient neutralization of foot-and-mouth disease virus by monovalent antibody binding.
Verdaguer N, Fita I, Domingo E, Mateu MG
J Virol 71: 9813-9816. (1997)
Conformation of the hypervariable region L3 without the key proline residue.
Guarné A, Bravo J, Calvo J, Lozano F, Vives J, Fita I
Protein Sci 5: 167-169. (1996)
Guarné A, Kirchweger R, Verdaguer N, Liebig HD, Blaas D, Skern T, Fita I
Protein Sci 5: 1931-1933. (1996)
Structure of the heme d of Penicillium vitale and Escherichia coli catalases.
Murshudov GN, Grebenko AI, Barynin V, Dauter Z, Wilson KS, Vainshtein BK, Melik-Adamyan W, Bravo J, Ferrán JM, Ferrer JC, Switala J, Loewen PC, Fita I
J Biol Chem 271: 8863-8868. (1996)
Verdaguer N, Mateu MG, Bravo J, Domingo E, Fita I
J Mol Biol 256: 364-376. (1996)
Crystal structure of catalase HPII from Escherichia coli.
Bravo J, Verdaguer N, Tormo J, Betzel C, Switala J, Loewen PC, Fita I
Structure 3: 491-502. (1995)
Molecular evolution of aphthoviruses.
Domingo E, Mateu MG, Escarmís C, Martínez-Salas E, Andreu D, Giralt E, Verdaguer N, Fita I
Virus Genes 11: 197-207. (1995)
Gomis-Rüth FX, Fita I, Kiefersauer R, Huber R, Avilés FX, Navaza J
Acta Crystallogr D Biol Crystallogr 51: 819-823. (1995)
Marina A, Bravo J, Fita I, Rubio V
Proteins 22: 193-196. (1995)
Docking of a human rhinovirus neutralizing antibody onto the viral capsid.
Tormo J, Centeno NB, Fontana E, Bubendorfer T, Fita I, Blaas D
Proteins 23: 491-501. (1995)
Valero ML, Camarero JA, Adeva A, Verdaguer N, Fita I, Mateu MG, Domingo E, Giralt E, Andreu D
Biomed Pept Proteins Nucleic Acids 1: 133-140. (1995)
Verdaguer N, Mateu MG, Andreu D, Giralt E, Domingo E, Fita I
EMBO J 14: 1690-1696. (1995)
de la Cruz X, Mark AE, Tormo J, Fita I, van Gunsteren WF
J Mol Biol 236: 1186-1195. (1994)
Structure of ribonuclease A derivative II at 2.1-A resolution.
Boqué L, Gràcia Coll M, Vilanova M, Cuchillo CM, Fita I
J Biol Chem 269: 19707-19712. (1994)
Marina A, Bravo J, Fita I, Rubio V
J Mol Biol 235: 1345-1347. (1994)
Tormo J, Blaas D, Parry NR, Rowlands D, Stuart D, Fita I
EMBO J 13: 2247-2256. (1994)
Verdaguer N, Mateu MG, Bravo J, Tormo J, Giralt E, Andreu D, Domingo E, Fita I
Proteins 18: 201-203. (1994)
Tabernero L, Verdaguer N, Coll M, Fita I, van der Marel GA, van Boom JH, Rich A, Aymamí J
Biochemistry 32: 8403-8410. (1993)
Representation of noncovalent interactions in protein structures.
de la Cruz X, Reverter J, Fita I
J Mol Graph 10: 96-100, 110. (1992)
Tormo J, Puiggali J, Vives J, Fita I, Lloveras J, Bella J, Aymamí J, Subirana JA
Biopolymers 32: 643-648. (1992)
Tormo J, Stadler E, Skern T, Auer H, Kanzler O, Betzel C, Blaas D, Fita I
Protein Sci 1: 1154-1161. (1992)
Molecular structure of a complete turn of A-DNA.
Verdaguer N, Aymami J, Fernández-Forner D, Fita I, Coll M, Huynh-Dinh T, Igolen J, Subirana JA
J Mol Biol 221: 623-635. (1991)
Tormo J, Fita I, Kanzler O, Blaas D
J Biol Chem 265: 16799-16800. (1990)
Crystallization and preliminary X-ray diffraction analysis of catalase HPII from Escherichia coli.
Tormo J, Fita I, Switala J, Loewen PC
J Mol Biol 213: 219-220. (1990)
Molecular structure of L-lysyl-L-tyrosyl-L-serine acetate.
Verdaguer N, Fita I, Subirana JA
Int J Biol Macromol 12: 315-320. (1990)
Urpi L, Ridoux JP, Liquier J, Verdaguer N, Fita I, Subirana JA, Iglesias F, Huynh-Dinh T, Igolen J, Taillandier E
Nucleic Acids Res 17: 6669-6680. (1989)
Structure of d(CACGTG), a Z-DNA hexamer containing AT base pairs.
Coll M, Fita I, Lloveras J, Subirana JA, Bardella F, Huynh-Dinh T, Igolen J
Nucleic Acids Res 16: 8695-8705. (1988)
Molecular structure of L-lysyl-L-alanyl-L-alanine: a tripeptide found in histone H1.
Verdaguer N, Urpí L, Fita I, Subirana JA
Biopolymers 27: 1887-1896. (1988)
Comparison of beef liver and Penicillium vitale catalases.
Melik-Adamyan WR, Barynin VV, Vagin AA, Borisov VV, Vainshtein BK, Fita I, Murthy MR, Rossmann MG
J Mol Biol 188: 63-72. (1986)
Modelling and refinement of the crystal structure of nucleoprotamine from Gibbula divaricata.
Puigjaner LC, Fita I, Arnott S, Chandrasekaran R, Subirana JA
J Biomol Struct Dyn 3: 1067-1078. (1986)
Three-dimensional structure of catalase from Penicillium vitale at 2.0 A resolution.
Vainshtein BK, Melik-Adamyan WR, Barynin VV, Vagin AA, Grebenko AI, Borisov VV, Bartels KS, Fita I, Rossmann MG
J Mol Biol 188: 49-61. (1986)
The structure of a T = 1 icosahedral empty particle from southern bean mosaic virus.
Erickson JW, Silva AM, Murthy MR, Fita I, Rossmann MG
Science 229: 625-629. (1985)
The active center of catalase.
Fita I, Rossmann MG
J Mol Biol 185: 21-37. (1985)
The NADPH binding site on beef liver catalase.
Fita I, Rossmann MG
Proc Natl Acad Sci U S A 82: 1604-1608. (1985)
Fita I, Campos JL, Puigjaner LC, Subirana JA
J Mol Biol 167: 157-177. (1983)
The subunit structure of chromatin fibres.
Subirana JA, Muñoz-Guerra S, Martínez AB, Pérez-Grau L, Marcet X, Fita I
Chromosoma 83: 455-471. (1981)
Project funding
Ongoing Projects
Reference: PID2021-125632OB-C21
Title: Estructura y función de factores de virulencia en micoplasmas.
Period: 2022-2025.
Role: PI.
Agency: Ministerio de Ciencia e Innovación.
Proyecto PID2021-125632OB-C21 financiado por:
Reference: 2014 MDM-2014-0435
Title: Unidad de Excelencia María de Maeztu. Unidad Departamento de Biología Estructural
Period: 01/07/15 – 30/12/19.
Role: Co-PI.
Agency: Ministerio de Economía y Competitividad.
Reference: PGC2018-101265-B-I00
Title: The human pathogen Micoplasma Genitalum Motility Machinery.
Period: 01/01/2019-31/12/2021.
Role: PI.
Agency: Ministerio de Economía y Competitividad.
Proyecto PGC2018-101265-B-I00 financiado por:
Reference: 2017 SGR-1189
Title: Ajuts a Grups Consolidats
Period: 01/01/2017 – 31/12/2020.
Role: Co-PI.
Agency: AGAUR-Generalitat de Catalunya
Concluded projects
Reference: BFU2015-71092-P
Title: The human pathogen Micoplasma Genitalum Motility Machinery.
Period: 01/01/2016-31/12/2018.
Role: PI.
Agency: Ministerio de Economía y Competitividad.
Vacancies/Jobs
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