Protein & Nucleic Acid Complexes and Molecular Machines – Miquel Coll

Projects

• Transcription regulation.
• DNA replication control.
• Horizontal gene transfer.
• DNA structure and drug-DNA interactions.
• DNA packaging in viruses.
• Viral replication machinery.
• Protein complexes, epigenetic regulation of gene expression and cancer.

Lab people

Selected publications

Atomic structure of the Epstein-Barr virus portal

Machón, C., Fàbrega-Ferrer, M., Zhou, D., Cuervo, A., Carrascosa, J.L., Stuart, D.I. & Coll, M.

Nature Communications 10, 3891. doi: 10.1038/s41467-019-11706-8.

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Structures of T7 bacteriophage portal and tail suggest a viral DNA retention and ejection mechanism

Cuervo, A., Fàbrega-Ferrer, M., Machón, C., Conesa, J.J., Fernández, F.J, Pérez-Luque, R., Pérez-Ruiz, M., Pous, J, Vega, M.C., Carrascosa, J.L. & Coll, M.

Nature Communications 10, 3746. doi: 10.1038/s41467-019-11705-9.

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Structural basis for DNA binding specificity by the auxin-dependent ARF transcription factors

Boer DR, Freire-Rios A, van den Berg WA, Saaki T, Manfield IW, Kepinski S, López-Vidrieo I, Franco-Zorrilla JM, de Vries SC, Solano R, Weijers D and Coll M.

Cell,2014. 156 (3), 577-89

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Thread insertion of a bis(dipyridophenazine) diruthenium complex into the DNA double helix by the extrusion of AT base pairs and cross-linking of DNA duplexes

Boer DR, Wu L, Lincoln P and Coll M.

Angew Chem Int Edit, 2014. 53 (7), 1949-52

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Human mitochondrial transcription factor A induces a U-turn structure in the light strand promoter

Rubio-Cosials A, Sidow JF, Jiménez-Menéndez N, Fernández-Millán P, Montoya J, Jacobs HT, Coll M, Bernadó P and Solà M.

Nat Struct Mol Biol, 2011. 18 (11), 1281-9

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The structure of a transcription activation subcomplex reveals how σ(70) is recruited to PhoB promoters

Blanco AG, Canals A, Bernués J, Solà M and Coll M.

Embo J, 2011. 30 3776-3785

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Structure and inhibition of herpesvirus DNA packaging terminase nuclease domain

Nadal M, Mas PJ, Blanco AG, Arnan C, Solà M, Hart DJ and Coll M.

P Natl Acad Sci Usa, 2010. 107 (37), 16078-83

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Human mitochondrial mTERF wraps around DNA through a left-handed superhelical tandem repeat

Jiménez-Menéndez N, Fernández-Millán P, Rubio-Cosials A, Arnan C, Montoya J, Jacobs HT, Bernadó P, Coll M, Usón I and Solà M.

Nat Struct Mol Biol, 2010. 17 (7), 891-3

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Plasmid replication initiator RepB forms a hexamer reminiscent of ring helicases and has mobile nuclease domains

Boer DR, Ruíz-Masó JA, López-Blanco JR, Blanco AG, Vives-Llàcer M, Chacón P, Usón I, Gomis-Rüth FX, Espinosa M, Llorca O, del Solar G and Coll M.

Embo J, 2009. 28 (11), 1666-78

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Molecular recognition of a three-way DNA junction by a metallosupramolecular helicate

Oleksy A, Blanco AG, Boer R, Usón I, Aymamí J, Rodger A, Hannon MJ and Coll M.

Angew Chem Int Edit, 2006. 45 (8), 1227-31

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The structure of phage φ29 transcription regulator p4-DNA complex reveals an N-hook motif for DNA binding

Badia D, Camacho A, Pérez-Lago L, Escandón C, Salas M and Coll M

Mol Cell, 2006. 22 73-81

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Recognition and processing of the origin of transfer DNA by conjugative relaxase TrwC

Guasch A, Lucas M, Moncalián G, Cabezas M, Pérez-Luque R, Gomis-Rüth FX, de la Cruz F and Coll M.

Nat Struct Mol Biol, 2003. 10 (12), 1002-10

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The bacterial conjugation protein TrwB resembles ring helicases and F1-ATPase

Gomis-Rüth FX, Moncalián G, Pérez-Luque R, González A, Cabezón E, de la Cruz F and Coll M.

Nature, 2001. 409 (6820), 637-41

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Crystal structure of a DNA Holliday junction

Ortiz-Lombardía M, González A, Eritja R, Aymamí J, Azorín F and Coll M.

Nat Struct Mol Biol, 1999. 6 (10), 913-7

All publications

Structures of pMV158 replication initiator RepB with and without DNA reveal a flexible dual-function protein.

Machón, C., Ruiz-Masó, J.A.,  Amodio, J., Boer, D.R., Bordanaba-Ruiseco, L., Bury, K., Konieczny, I., del Solar, G. and Miquel Coll.

Nucleic Acids Research (2023), doi: 10.1093/nar/gkac1271

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Using a partial atomic model from medium-resolution cryo-EM to solve a large crystal structure.

Fàbrega-Ferrer, M., Cuervo, A., Fernández, F.J., Machón, C., Pérez-Luque, R., Pous, J., Vega, M.C., Carrascosa, J.L. & Coll, M.

Acta Crystallogr D Struct Biol. 2021 Jan 1;77(Pt 1):11-18. doi: 10.1107/S2059798320015156.

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Structure-Driven Discovery of α,γ-Diketoacid Inhibitors Against UL89 Herpesvirus Terminase.

Bongarzone, S., Nadal, M., Kaczmarska, Z., Machón, C., Álvarez, M., Albericio, F. & Coll M.

ACS Omega. 2018 Aug 1;3(8):8497-8505. doi: 10.1021/acsomega.8b01472.

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Atomic structure of the Epstein-Barr virus portal

Machón, C., Fàbrega-Ferrer, M., Zhou, D., Cuervo, A., Carrascosa, J.L., Stuart, D.I. & Coll, M.

Nature Communications 10, 3891. doi: 10.1038/s41467-019-11706-8.

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Structures of T7 bacteriophage portal and tail suggest a viral DNA retention and ejection mechanism

Cuervo, A., Fàbrega-Ferrer, M., Machón, C., Conesa, J.J., Fernández, F.J, Pérez-Luque, R., Pérez-Ruiz, M., Pous, J, Vega, M.C., Carrascosa, J.L. & Coll, M.

Nature Communications 10, 3746. doi: 10.1038/s41467-019-11705-9.

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tRNA deamination by ADAT requires substrate-specific recognition mechanisms and can be inhibited by tRFs

Roura Frigolé H, Camacho N, Castellví Coma M, Fernández-Lozano C, García-Lema J, Rafels-Ybern À, Canals A, Coll M, Ribas de Pouplana L.

RNA. 2019 May;25(5):607-619.

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Insights into the inhibited form of the redox-sensitive SufE-like sulfur acceptor CsdE

Peña-Soler E, Aranda J, López-Estepa M, Gómez S, Garces F, Coll M, Fernández FJ, Tuñon I, Vega MC.

PLoS One. 2017 Oct 18;12(10):e0186286.

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Structural basis of a histidine-DNA nicking/joining mechanism for gene transfer and promiscuous spread of antibiotic resistance

Pluta R, Boer DR, Lorenzo-Díaz F, Russi S, Gómez H, Fernández-López C, Pérez-Luque R, Orozco M, Espinosa M, Coll M.

Proc Natl Acad Sci U S A. 2017 Aug 8;114(32):E6526-E6535.

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Intercalative DNA binding of the marine anticancer drug variolin B

Canals A, Arribas-Bosacoma R, Albericio F, Álvarez M, Aymamí J, Coll M.

Scientific Reports. 2017 Jan 4;7:39680.

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Irreversible inhibitors of the 3C protease of Coxsackie virus through templated assembly of protein-binding fragments

Becker D, Kaczmarska Z, Arkona C, Schulz R, Tauber C, Wolber G, Hilgenfeld R, Coll M, Rademann J.

Scientific Reports. 2016 Jul 14;6:29232.

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A C2HC zinc finger is essential for the RING-E2 interaction of the ubiquitin ligase RNF125.

Bijlmakers MJ, Teixeira JM, Boer R, Mayzel M, Puig-Sàrries P, Karlsson G, Coll M, Pons M, Crosas B.

Scientific Reports. Jul 14;6:29232. (2016)

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Conformational plasticity of RepB, the replication initiator protein of promiscuous streptococcal plasmid pMV158

Boer DR, Ruiz-Masó JA, Rueda M, Petoukhov MV, Machón C, Svergun DI, Orozco M, Del Solar G and Coll M.

Scientific Reports, 6 20915 (2016)

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Plasmid Rolling-Circle Replication

Ruiz-Masó JA, MachóN C, Bordanaba-Ruiseco L, Espinosa M, Coll M and Del Solar G.

Microbiology Spectrum, 3 (1), PLAS-0035 (2015)

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The structure of the complex between α-tubulin, TBCE and TBCB reveals a tubulin dimer dissociation mechanism

Serna M, Carranza G, Martín-Benito J, Janowski R, Canals A, Coll M, Zabala JC and Valpuesta JM.

Journal of Cell Science, 128 (9), 1824-34 (2015)

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The crystal structure and small-angle X-ray analysis of CsdL/TcdA reveal a new tRNA binding motif in the MoeB/E1 superfamily

López-Estepa M, Ardá A, Savko M, Round A, Shepard WE, Bruix M, Coll M, Fernández FJ, Jiménez-Barbero J and Vega MC.

PLoS One, 10 (4), e0118606 (2015)

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Structural analysis and mutant growth properties reveal distinctive enzymatic and cellular roles for the three major L-alanine transaminases of Escherichia coli

Peña-Soler E, Fernandez FJ, López-Estepa M, Garces F, Richardson AJ, Quintana JF, Rudd KE, Coll M and Vega MC.

PLoS One, 9 (7), e102139 (2014)

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Structural basis for DNA binding specificity by the auxin-dependent ARF transcription factors

Boer DR, Freire-Rios A, van den Berg WA, Saaki T, Manfield IW, Kepinski S, López-Vidrieo I, Franco-Zorrilla JM, de Vries SC, Solano R, Weijers D and Coll M.

Cell, 156 (3), 577-89 (2014)

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Thread insertion of a bis(dipyridophenazine) diruthenium complex into the DNA double helix by the extrusion of AT base pairs and cross-linking of DNA duplexes

Boer DR, Wu L, Lincoln P and Coll M.

Angewandte Chemie Int Edit, 53 (7), 1949-52 (2014)

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New features of vault architecture and dynamics revealed by novel refinement using the deformable elastic network approach

Casañas A, Querol-Audí J, Guerra P, Pous J, Tanaka H, Tsukihara T, Verdaguer N and Fita I.

 Acta Crystallographica Section D, 69 (Pt 6), 1054-61 (2013)

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A novel family of soluble minimal scaffolds provides structural insight into the catalytic domains of integral membrane metallopeptidases

López-Pelegrín M, Cerdà-Costa N, Martínez-Jiménez F, Cintas-Pedrola A, Canals A, Peinado JR, Marti-Renom MA, López-Otín C, Arolas JL and Gomis-Rüth FX.

Journal of Biological Chemistry, 288 (29), 21279-94 (2013)

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Structure and non-structure of centrosomal proteins

Dos Santos HG, Abia D, Janowski R, Mortuza G, Bertero MG, Boutin M, Guarín N, Méndez-Giraldez R, Nuñez A, Pedrero JG, Redondo P, Sanz M, Speroni S, Teichert F, Bruix M, Carazo JM, Gonzalez C, Reina J, Valpuesta JM, Vernos I, Zabala JC, Montoya G, Coll M, Bastolla U and Serrano L.

PLoS One, 8 (5), e62633 (2013)

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Functional properties and structural requirements of the plasmid pMV158-encoded MobM relaxase domain

Fernández-López C, Pluta R, Pérez-Luque R, Rodríguez-González L, Espinosa M, Coll M, Lorenzo-Díaz F and Boer DR.

Journal of Bacteriology, 195 (13), 3000-8 (2013)

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Nicking activity of the pMV158 MobM relaxase on cognate and heterologous origins of transfer

Fernández-López C, Lorenzo-Díaz F, Pérez-Luque R, Rodríguez-González L, Boer R, Lurz R, Bravo A, Coll M and Espinosa M.

Plasmid, 70 (1), 120-30 (2013)

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σ70 and PhoB activator: getting a better grip

Canals A, Blanco AG and Coll M.

Transcription, 3 (4), 160-4 (2012)

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PhoB transcriptional activator binds hierarchically to pho box promoters

Blanco AG, Canals A and Coll M.

Biological Chemistry, 393 (10), 1165-71 (2012)

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Structure and mechanism of a cysteine sulfinate desulfinase engineered on the aspartate aminotransferase scaffold

Fernandez FJ, de Vries D, Peña-Soler E, Coll M, Christen P, Gehring H and Vega MC.

Biochimica et Biophysica Acta (BBA) – Proteins and Proteomics, 1824 (2), 339-49 (2012)

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Human mitochondrial transcription factor A induces a U-turn structure in the light strand promoter

Rubio-Cosials A, Sidow JF, Jiménez-Menéndez N, Fernández-Millán P, Montoya J, Jacobs HT, Coll M, Bernadó P and Solà M.

Nature Structural and Molecular Biology, 18 (11), 1281-9 (2011)

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Site-directed mutagenesis of mouse glutathione transferase P1-1 unlocks masked cooperativity, introduces a novel mechanism for ‘ping pong’ kinetic behaviour, and provides further structural evidence for participation of a water molecule in proton abstraction from glutathione.

McManus G, Costa M, Canals A, Coll M and Mantle TJ.

The Febs Journal, 278 (2), 273-81 (2011)

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Picornavirus non-structural proteins as targets for new anti-virals with broad activity

Norder H, De Palma AM, Selisko B, Costenaro L, Papageorgiou N, Arnan C, Coutard B, Lantez V, De Lamballerie X, Baronti C, Solà M, Tan J, Neyts J, Canard B, Coll M, Gorbalenya AE and Hilgenfeld R.

Antiviral Research, 89 (3), 204-18 (2011)

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The UlaG protein family defines novel structural and functional motifs grafted on an ancient RNase fold

Fernandez FJ, Garces F, Lopez-Estepa M, Aguilar J, Baldoma L, Coll M, Badia J and Vega MC.

BMC Evolutionary Biology, 11 (1), 273 (2011)

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Structural basis for antiviral inhibition of the main protease, 3C, from human enterovirus 93

Costenaro L, Kaczmarska Z, Arnan C, Janowski R, Coutard B, Solà M, Gorbalenya AE, Norder H, Canard B and Coll M.

Journal of Virology, 85 (20), 10764-73 (2011)

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Structural insights into transcription complexes

Berger I, Blanco AG, Boelens R, Cavarelli J, Coll M, Folkers GE, Nie Y, Pogenberg V, Schultz P, Wilmanns M, Moras D and Poterszman A.

Journal of Structural Biology, 175 (2), 135-46 (2011)

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The MobM relaxase domain of plasmid pMV158: thermal stability and activity upon Mn2+ and specific DNA binding

Lorenzo-Díaz F, Dostál L, Coll M, Schildbach JF, Menéndez M and Espinosa M.

Nucleic Acids Research, 39 (10), 4315-29 (2011)

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The structure of a transcription activation subcomplex reveals how σ(70) is recruited to PhoB promoters

Blanco AG, Canals A, Bernués J, Solà M and Coll M.

The Embo Journal, 30 3776-3785 (2011)

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Self-assembly of functionalizable two-component 3D DNA arrays through the induced formation of DNA three-way-junction branch points by supramolecular cylinders

Boer DR, Kerckhoffs JM, Parajo Y, Pascu M, Usón I, Lincoln P, Hannon MJ and Coll M.

Angewandte Chemie Int Edit, 49 (13), 2336-9 (2010)

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Molecular architecture of the Mn2+-dependent lactonase UlaG reveals an RNase-like metallo-beta-lactamase fold and a novel quaternary structure

Garces F, Fernández FJ, Montellà C, Penya-Soler E, Prohens R, Aguilar J, Baldomà L, Coll M, Badia J and Vega MC.

Journal of Molecular Biology, 398 (5), 715-29 (2010)

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The structure of RNA-free Rho termination factor indicates a dynamic mechanism of transcript capture

Canals A, Usón I and Coll M.

Journal of Molecular Biology, 400 (1), 16-23 (2010)

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Structure and inhibition of herpesvirus DNA packaging terminase nuclease domain

Nadal M, Mas PJ, Blanco AG, Arnan C, Solà M, Hart DJ and Coll M.

P Natl Acad Sci Usa, 107 (37), 16078-83 (2010)

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Human mitochondrial mTERF wraps around DNA through a left-handed superhelical tandem repeat

Jiménez-Menéndez N, Fernández-Millán P, Rubio-Cosials A, Arnan C, Montoya J, Jacobs HT, Bernadó P, Coll M, Usón I and Solà M.

Nature Structural and Molecular Biology, 17 (7), 891-3 (2010)

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Mechanical network in titin immunoglobulin from force distribution analysis

Stacklies W, Vega MC, Wilmanns M and Gräter F.

Plos Comput Biol, 5 (3), e1000306 (2009)

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Plasmid replication initiator RepB forms a hexamer reminiscent of ring helicases and has mobile nuclease domains

Boer DR, Ruíz-Masó JA, López-Blanco JR, Blanco AG, Vives-Llàcer M, Chacón P, Usón I, Gomis-Rüth FX, Espinosa M, Llorca O, del Solar G and Coll M.

The Embo Journal, 28 (11), 1666-78 (2009)

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DNA-binding drugs caught in action: the latest 3D pictures of drug-DNA complexes

Boer DR, Canals A and Coll M.

Dalton Transactions (3), 399-414 (2009)

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Cloning, expression, purification and crystallization of the Rho transcription termination factor from Thermotoga maritima

Canals A and Coll M.

Protein Expression and Purification, 65 (2), 174-8 (2009)

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Molecular machinery for DNA translocation in bacterial conjugation

Russi S, Boer R and Coll M

In Plasmids: Current Research and Future Trends, Horizon Scientific Press, – 183-13 (2008)

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The VIZIER project: preparedness against pathogenic RNA viruses

Coutard B, Gorbalenya AE, Snijder EJ, Leontovich AM, Poupon A, De Lamballerie X, Charrel R, Gould EA, Gunther S, Norder H, Klempa B, Bourhy H, Rohayem J, L’hermite E, Nordlund P, Stuart DI, Owens RJ, Grimes JM, Tucker PA, Bolognesi M, Mattevi A, Coll

Antiviral Research, 78 (1), 37-46 (2008)

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Quaternary structural transitions in the DeoR-type repressor UlaR control transcriptional readout from the L-ascorbate utilization regulon in Escherichia coli

Garces F, Fernández FJ, Gómez AM, Pérez-Luque R, Campos E, Prohens R, Aguilar J, Baldomà L, Coll M, Badía J and Vega MC

Biochemistry, 47 (44), 11424-33 (2008)

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Overproduction, crystallization and preliminary X-ray analysis of the putative L-ascorbate-6-phosphate lactonase UlaG from Escherichia coli

Garces F, Fernández FJ, Pérez-Luque R, Aguilar J, Baldomà L, Coll M, Badía J and Vega MC.

Acta Crystallographica Section F, 64 (Pt 1), 36-8 (2008)

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The X-ray crystal structures of two constitutively active mutants of the Escherichia coli PhoB receiver domain give insights into activation

Arribas-Bosacoma R, Kim SK, Ferrer-Orta C, Blanco AG, Pereira PJB, Gomis-Rüth X, Wanner BL, Coll M and Solà M

Journal of Molecular Biology, 366 626-41 (2007)

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Molecular recognition of a three-way DNA junction by a metallosupramolecular helicate

Oleksy A, Blanco AG, Boer R, Usón I, Aymamí J, Rodger A, Hannon MJ and Coll M.

Angewandte Chemie Int Edit, 45 (8), 1227-31 (2006)

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Application of the use of high-throughput technologies to the determination of protein structures of bacterial and viral pathogens

Fogg MJ, Alzari P, Bahar M, Bertini I, Betton JM, Burmeister WP, Cambillau C, Canard B, Carrondo M, Coll M, Daenke S, Dym O, Egloff MP, Enguita FJ, Geerlof A, Haouz A, Jones TA, Ma Q, Manicka SN, Migliardi M, Nordlund P, Owens RJ, Peleg Y, Schneider

Acta Crystallographica Section D, 62 1196-07 (2006)

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Cut and move: protein machinery for DNA processing in bacterial conjugation

Gomis-Rüth FX and Coll M

Current Opinion in Structural Biology, 16 744-52 (2006)

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The cofactor-induced pre-active conformation in PhoB

Solà M, Drew DL, Blanco AG, Gomis-Rüth FX and Coll M

Acta Crystallographica Section D, 62 1046-57 (2006)

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Unveiling the molecular mechanism of a conjugative relaxase: The structure of TrwC complexed with a 27-mer DNA comprising the recognition hairpin and the cleavage site

Boer R, Russi S, Guasch A, Lucas M, Blanco AG, Pérez-Luque R, Coll M and de la Cruz F

Journal of Molecular Biology, 358 857-69 (2006)

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The structure of phage φ29 transcription regulator p4-DNA complex reveals an N-hook motif for DNA binding

Badia D, Camacho A, Pérez-Lago L, Escandón C, Salas M and Coll M

Molecular Cell, 22 73-81 (2006)

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The anticancer agent ellipticine unwinds DNA by intercalative binding in an orientation parallel to base pairs.

Canals A, Purciolas M, Aymamí J, Coll M.

Acta Crystallographica Section D Biol Crystallogr., Pt 7 (61), 1009-1012 (2005)

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Crystal structure of an iron-dependent group III dehydrogenase that interconverts L-lactaldehyde and L-1,2-propanediol in Escherichia coli

Montella C, Bellsolell L, Pérez-Luque R, Badía J, Baldoma L, Coll M, Aguilar J.

Journal of Bacteriology, 14 (187), 4957-4966 (2005)

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Recognition and processing of the origin of transfer DNA by conjugative relaxase TrwC

Guasch A, Lucas M, Moncalián G, Cabezas M, Pérez-Luque R, Gomis-Rüth FX, de la Cruz F and Coll M.

Nature Structural and Molecular Biology, 10 (12), 1002-10 (2003)

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Conjugative plasmid protein TrwB, an integral membrane type IV secretion system coupling protein. Detailed structural features and mapping of the active site cleft

Gomis-Rüth FX, Moncalían G, de la Cruz F, Coll M.

Journal of Biological Chemistry, 9 (277), 7556-7566 (2002)

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Structure of the DNA-bound T-box domain of human TBX3, a transcription factor responsible for ulnar-mammary syndrome.

Coll M, Seidman JG, Müller CW.

Structure, 3 (10), 343-356 (2002)

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Crystallization and preliminary X-ray analysis of the antimalarial and cytotoxic alkaloid cryptolepine complexed with the DNA fragment d(CCTAGG)2.

Lisgarten JN, Pous J, Coll M, Wright CW, Aymami J.

Acta Crystallographica Section D Biol Crystallogr., Pt 2 (58), 312-313 (2002)

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Crystallization and preliminary X-ray analysis of the DNA decamers d(CCGGATCCGG) and d(CCGGCGCCGG)

Aymami J, Pous J, Lisgarten JN, Coll M.

Acta Crystallographica Section D Biol Crystallogr., Pt 2 (58), 310-311 (2002)

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Detailed architecture of a DNA translocating machine: the high-resolution structure of the bacteriophage phi29 connector particle.

Guasch A, Pous J, Ibarra B, Gomis-Rüth FX, Valpuesta JM, Sousa N, Carrascosa JL, Coll M.

Journal of Molecular Biology, 4 (315), 663-676 (2002)

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The antimalarial and cytotoxic drug cryptolepineintercalates into DNA at cytosine-cytosine sites

Lisgarten JN, Coll M, Portugal J, Wright CW & Aymamí J

Nature Structural and Molecular Biology,; (9), 57-60 (2002)

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Trypanosoma cruzi macrophage infectivity potentiator has arotamase core and a highly exposed α-helix

Pereira PJB, Vega MC, González-Rey E, Fernández-Carazo R, Macedo-Ribeiro S, Gomis-Rüth FX, González A & Coll M

EMBO reports (3), 88-94 (2002)

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Tandem DNA recognition by PhoB, a two-component signal transduction transcriptional activator

Blanco AG, Sola M, Gomis-Rüth FX & Coll M

Structure (10), 1-20 (2002)

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The bacterial conjugation protein TrwB resembles ring helicases and F1-ATPase

Gomis-Rüth FX, Moncalián G, Pérez-Luque R, González A, Cabezón E, de la Cruz F and Coll M.

Nature, 409 (6820), 637-41 (2001)

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Review: postchaperonin tubulin folding cofactors and their role in microtubule dynamics

Lopez-Fanarraga M, Avila J, Guasch A, Coll M, Zabala JC.

Journal of Structural Biology, 2 (135), 219-229 (2001)

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The structure of an engineered domain-swapped ribonuclease dimer and its implications for the evolution of proteins toward oligomerization.

Canals A, Pous J, Guasch A, Benito A, Ribó M, Vilanova M, Coll M.

Structure, 10 (9), 967-976 (2001)

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Structure of TrwB, a gatekeeper in bacterial conjugation

Gomis-Rüth FX, Coll M.

The International Journal of Biochemistry & Cell Biology, 9 (33), 839-843 (2001)

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Plasmid transcriptional repressor CopG oligomerises to render helical superstructures unbound and in complexes with oligonucleotides

Costa M, Solà M, del Solar G, Eritja R, Hernández-Arriaga AM, Espinosa M, Gomis-Rüth FX, Coll M.

Journal of Molecular Biology., 2 (310), 403-417 (2001)

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The crystal structure of the inhibitor-complexed carboxypeptidase D domain II and the modeling of regulatory carboxypeptidases

Aloy P, Companys V, Vendrell J, Aviles FX, Fricker LD, Coll M, Gomis-Rüth FX.

Journal of Biological Chemistry., 19 (276), 16177-16184 (2001)

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Solving a 300-kDa multimeric protein by low-resolution MAD phasing and averaging/phase extension

Gomis-Rüth FX, Coll M.

Acta Crystallographica Section D Biol Crystallogr., Pt 6 (57), 489-505 (2001)

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Three-dimensional structure of human biliverdin-IXβ reductase, an early fetal bilirubin-IXβ producing enzyme

Pereira PJ, Macedo-Ribeiro S, Párraga A, Pérez-Luque R, Cunningham O, Darcy K, Mantle TJ, Coll M.

Nature Structural and Molecular Biology, 3 (8), 215-220 (2001)

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Three-dimensional structure of human RNase 1 delta N7 at 1.9 A resolution.

Pous J, Mallorquí-Fernández G, Peracaula R, Terzyan SS, Futami J, Tada H, Yamada H, Seno M, de Llorens R, Gomis-Rüth FX, Coll M.

Acta Crystallographica Section D Biol Crystallogr, Pt 4 (57), 498-505 (2001)

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Structure of human biliverdin-IXβ reductase, an earlyfetal bilirubin-IXβ producing enzyme

Pereira PJ, Macedo-Ribeiro S, Párraga A, Pérez-Luque R, Cunningham O, Darcy K, Mantle TJ and Coll M

Nature Structural and Molecular Biology, 3 (8), 215-220 (2001)

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Crystal structure of a DNA Holliday junction

Ortiz-Lombardía M, González A, Eritja R, Aymamí J, Azorín F and Coll M.

Nature Structural and Molecular Biology, 6 (10), 913-7 (1999)

Project funding

Ongoing Projects

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Reference: PID2020-120141GB-I00

Title: Biología estructural de complejos de proteínas y ácidos nucleicos implicados en enfermedades infecciosas humanas

Period: 01/09/2021-31/08/2024.

Role: PI

Agency: Ministerio de Ciencia e Innovación.

Proyecto PID2020-120141GB-I00 financiado por:

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Concluded Projects

Reference: BFU2017-83720-P
Title: Structural biology of genic expression and DNA translocation regulation systems”
Period: 01/01/2018-31/12/2020.

Role: PI
Agency: Ministerio de Economía y Competitividad.

Proyecto BFU2017-83720-P financiado por:

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Reference: RTC-2016-5686-1
Title: Desarrollo de Tratamientos para enfermedades raras de depósito lisosomal
Period: 15/11/16 – 31/12/18.

Role: Co-PI
Agency: Ministerio de Economía y Competitividad.

Proyecto RTC-2016-5686-1 financiado por:

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Reference: BFU2014-53550-P
Title: Structure of DNA-binding proteins and complexes.
Period: 01/01/2015-31/12/2017.

Role: PI
Agency: Ministerio de Economía y Competitividad.

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Reference: MDM-2014-0435

Title: Appointment of the Department of Structural Biology of IBMB as a “María de Maeztu Unit of Excellence”

Total awarded: €2,000,000 (1.7.2015 – 31.12.2019)

Spanish Ministry of Economy and Competitivity.

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Reference: Ajuts a Grups de Recerca Consolidats 2014 SGR.
Title: Biologia estructural de complexos de proteïnes i àcids nucleics, i màquines moleculars.
Period: 2014-2016.

PI: M.Coll.

Agency: DIUE, Generalitat de Catalunya.

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Reference: BioMedTec 2013
Title: Validation of a new antiviral drug class against herpesvirus.
Period: 1/9/2013 – 31/8/2014.

IP: M. Coll.
Agency: La Caixa-IRB.

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Reference: Proyecto Plan Nacional de I+D+I BFU2011-22588

Title: Structure of DNA binding proteins and complexes (PRODNA).

Period: 2012-2014.

PI: M.Coll.

Agency: Ministerio de Educación y Ciencia.

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Reference: FP7 Collaborative Project, Large Scale Integrating Project,GA 260644.

Title: Small-molecule inhibitor leads versus emerging and neglected RNA viruses (SILVER).
Period: 2010-2014.

PI: M.Coll.

Agency: European Commission

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Reference: Ajuts a Grups de Investigació Consolidats 2009 SGR 1309.

Title: Grupo de cristalografía de proteínas.

Period: 2009-2012. PI: M.Coll.

Agency: DIUE, Generalitat de Catalunya.

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Reference: Proyecto Plan Nacional de I+D+I BFU2008-02372/BMC

Title: Structure of DNA binding proteins and complexes (PRODNA).

Period: 2009-2011.

PI: M.Coll.

Agency: Ministerio de Educación y Ciencia.

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Reference: Proyecto PETRI PET2007_0319_03

Title: Caracterización estructural de inhibidores de metiltransferasas.

Period: 2008 – 2010.

PI: M.Coll.

Agency: Ministerio de Educación y Ciencia.

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Reference: Acción complementaria de investigación BFU2007-29798-E

Title: Ayuda Complementaria al proyecto ESPINE2-COMPLEJOS: Del receptor al gen: Estructuras de complejos de vías de señalización, uniendo inmunología, neurobiología y cancer.

Period: 2008 –2009.

PI: M.Coll.

Agency: Ministerio de Educación y Ciencia.

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Reference: Proyecto Consolider. CSD2006-23.

Title: Centrosoma_3D: Hacia la comprensión estructural y funcional del centrosoma.

Period: 2006-2011.

PI: M.Coll.

Agency: Ministerio de Educación y Ciencia.

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Reference: Acción complementaria de investigación BFU2005-24123-E

Title: Ayuda complementaria al proyecto: Una aproximación multidisciplinaria para determinar las estructuras de los complejos proteicos en un organismo modelo.

Period: 2006 – 2010.

PI: M.Coll.

Agency: Ministerio de Educación y Ciencia.

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Reference: Acción complementaria de investigación BFU2005-24122-E

Title: Ayuda complementaria al proyecto: Genómica estructural comparativa para enzimas víricos

Period: 2006 – 2010.

PI: M.Coll.

Agency: Ministerio de Educación y Ciencia.

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Reference: EU Integrated Project LSHG-2006-031220

Title: SPINE2-Complexes: From Receptor to Gene: Structures of complexes from signalling pathways linking, immunology, neurobiology and cancer (Spine2-Complexes).

Period: 2006-2010.

PI: M.Coll.

Agency: European Commission.

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Reference: Proyecto Integrado VI PM LSHG-CT-2005-512028

Title: A Multidisciplinary Approach to Determine the Structures of Protein Complexes in a Model Organism (3D-REPERTOIRE).

Period: 2005-2009.

PI: M.Coll.

Agency: European Commission.

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Reference: Proyecto Plan Nacional de I+D+I BFU2005-06758/BMC

Title: Estructura de proteínas y complejos de unión al DNA

Period: 2005-2008.

PI: M.Coll.

Agency: Ministerio de Educación y Ciencia.

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Reference: Ayudas a Grupos de Investigación Consolidados 2005SGR-00280.

Title: Grupo de cristalografía de proteínas.

Period: 2005-2008.

PI: M.Coll.

Agency: CIRIT, Generalitat de Catalunya.

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Reference: Proyecto Fundació La Marató de TV3 052810.

Title: Epigenetic Chromatin Regulation Proteins as targets in Anticancer Strategy

Period: 2005 –2008.

PI: M.Coll.

Agency: Fundació La Marató de TV3.

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Reference: EU Integrated Project VI PM LSHG-CT-2004-511960

Title: Integrated structural genomics of viral enzymes involved in replication (VIZIER).

Period: 2004-2008.

PI: M.Coll.

Agency: European Comission

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Reference: Proyecto Integrado GEN2003-20642. Acción estrategica de genómica y proteómica

Title: Genómica estructural: aplicación a proteínas y complejos proteicos relacionados con el cáncer.

Period: 2004-2007.

PI: M.Coll.

Agency: Ministerio de Ciencia y Tecnología.

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