Towards understanding the regulation of histone H1 somatic subtypes with OMICs

Histone H1 is involved in the regulation of chromatin higher-order structure and compaction. In somatic cells, there are up to seven H1 variants, which are differentially expressed. We have analyzed Hi-C, ChIP-seq, and RNA-seq data to better understand the regulation of the H1 complement. The main findings of this analysis were that somatic H1 genes located in topologically associated domains (TADs) show higher expression than in boundary regions and that all H1 somatic subtypes are under transcriptional co-regulation. The latter may explain at least in part the variability of the H1 complement, its fluctuations during development, as well as the compensatory effects upon H1 knockout and knockdown.

Ponte I, Andrés M, Jordan A, Roque A (2020) Towards understanding the regulation of histone H1 somatic subtypes with OMICs. Journal of Molecular Biology doi: 10.1016/j.jmb.2020.166734.