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Neuromesodermal progenitors in development, evolution and regeneration
08 – 12 September 2020 | VIRTUAL
This EMBO Workshop was intended to cover the most recent work on the different aspects of the biology of a group of axial progenitors, referred to as neuromesodermal progenitors (NMPs), that play a fundamental role in the axial elongation of vertebrate embryos. The workshop aimed to stimulate discussions on the normal development and regeneration potential of these cells, as well as on methods to further direct NMPS differentiation towards specific cell lineages.
In the meeting Elisa Martí presented a novel role played by the TGF-beta/SMAD3 signalling in the dynamic events that lead to de novo lumen formation and that culminate in the formation of a 3-dimensional, secondary neural tube from NMPs. The findings of Marti’s group research will be relevant to understand caudal, skin-covered neural tube defects, amongst the most frequent birth defects detected in humans. This study was the PhD thesis of Elena Gonzalez-Gobartt and is now being continued by Jose Blanco-Ameijeiras, both students at IBMB.
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