Carica papaya pyroglutamine cyclotransferase (2006)
This enzyme is in charge of cyclization of N-terminal glutamine to yield pyroglutamate. Interestingly, while mammalian enzymes display an α/β-hydrolase fold, plant and bacterial forms are five-bladed β-propellers.
Carried out in the Proteolysis Lab and the Structural MitoLab in collaboration with UNIZYME Laboratories.
Human Transforming Growth Factor β-Ιnduced Protein (2017)
TGFBIp is an extracellular matrix component that interacts with integrins but also produces corneal deposits when mutated. Its multi-domain structure revealed the hotspots for clinical mutations.
Carried out in the Proteolysis Lab in collaboration with the group of J. Enghild.