Spatial genome organization, TGFβ, and biomolecular condensates: Do they talk during development?
In this review, we discuss how developmental signaling, epigenetics, and biochemical properties are coordinated to…
CSIC JAE Intro Scholarships Call / Convocatoria Becas JAE Intro del CSIC
The JAE Intro scholarships, aimed at initiation into research for university students, are remunerated and enable the subsequent…
THE NEW CRYO-EM PLATFORM is running!
THE NEW CRYO-EM PLATFORM is running! The IBMB-CSIC Cryo-EM Platform, located at ALBA synchrotron, opened its doors to users…
Characterization of the molecular mechanisms used by JmjC-lysine demethylases to regulate gene expression
Thesis presented on Tuesday, 27th of September by Marta Vicioso Mantis, at the Aula de Graus…
De novo design of immunoglobulin-like domains
The design of immunoglobulin-like domains from scratch has been a long-standing challenge. We have identified…
Proteína inmunodominante P116 del patógeno humano Mycoplasma pneumoniae: Un recipiente para el colesterol y otros lípidos esenciales
Thesis presented by Jesús Martín Romero, enrolled in the Biotechnology program at the University of…
Carme Gallego promoted to Investigadora Científica
The IBMB Direction board wants to share the good news that Carme Gallego has been promoted to…
A collaborative study between Dr. Liesa’s laboratory and Janssen R&D demonstrates that decreasing Drp1-mediated mitochondrial fission, using an FDA approved delivery method of siRNA to hepatocytes, exacerbates non-alcoholic steatohepatitis in mice.
The use of siRNA conjugated to N-acetyl-galactosamine (NAG-siRNA) is an approach approved by the FDA…
JmjC family of histone demethylases form nuclear condensates
With our work, we demonstrate that the JmjC-family of histone demethylases contain low complexity domains…
Dr. Liesa’s participated in a new study led by Dr. Wilson at the Center of Regenerative Medicine at Boston University, published in Science Advances titled “CRISPRi interrogation of COPD GWAS genes reveals the functional significance of desmoplakin in iPSC-derived alveolar epithelial cells”
An iPSC-CRISPRi platform allowed to investigate the functional significance of nine genes associated with Chronic…
JMJD3 intrinsically disordered region links the 3D-genome structure to TGFβ-dependent transcription activation
Summary In our study we demonstrated that TGFb drives multi-enhancer contacts and ultimately gene activation…