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Lab presentation

Nano-Bio-Systems Group

Nanotechnology has been defined as the science of developing and studying materials and devices that function within the nanometer scale. Nanomaterials exhibit unique chemical l and physical characteristics proper of the nanoscale. These unique traits result to the large surface to volume ratio of nanostructures.

Nanomedicine has emerged as a field which uses concepts from nanotechnology and medicine to prevent, diagnose, and treat diseases. A wide variety nanoparticles of are currently the subject of research for treatment and diagnosis.

Nano-bio-systems are unique tools in nanomedicine and nanobiology due to their novel nano-bio properties. Also, they can be tailored to the desired medical or biological application. Our group aim the developing the NanoBioSystem Technology for several biological medical research.

Projects

My research focus on the interdisciplinary field of NanoBioMedicine. We study basic science from a single molecule level to complexed organisms. We develop new tool and materials at the nanoscale level. With the aim of attaining most pressing biomedical challenges.

Main lines of research:

  • Nano-delivery system selectively to a specific cell.

I have designed novel carries that can be functionalized with several cargos and are cell specific. The system exploits the physical and topological properties of circular double-stranded (ds) DNA that makes a reversible ‘wrap’ using all type of nanoparticles by non-covalent interactions. These dsDNA-Nanostructures hybrids (named Nanosomes) are soluble, stable in cell culture medium and over a wide temperature range. Nanosomes can be designed to sense or carry a large intracellular cargo payload . Thus, Nanosomes represent a novel nano-delivery system, with multiple applications in biomedicine. A patent has been granted (Trigueros IP patent No. 13719162.3; 2015). Currently, we are able to delivery from a full genes, DNA oligos, siRNA, mRNA, chemotherapy drugs, antibodies and small proteins into cultured cells and retine explants with high efficiency and independent on endosome pathways. We are pioneer on cutting-edge scientific-interdisciplinary approach to study the complex bio-nanomaterial behaviour. And our approach has allowed us to identify and overcome the most challenges steps on cell-delivery.

  • Nanobiosensors:

Developing Ultrasensitive/Portable Detection Device based on different  NPs (Nanobiosensor). The devices are ultra-sensitive, specific, fast, compatible with different biological fluids, cheap, small, and portable. These advantages include a wide range of applications, from cancer biomarkers detection to infectious disease detection, prevention and eradication. Currently, use as a lab-research tool, they are being used in 4 hospitals based in Africa and in the Antarctic region.​

Lab people

Sonia Trigueros is an academic on the field of Nanomedicine.

She has a Ph.D. in Molecular Biology from IBMB-CSIC and Universidad de Barcelona.

She has been a postdoctoral researcher at Harvard and Oxford Universities. She is  currently  a  researcher  at  IBMB-CSIC,  Associated  Professor  at  the  University  of  Barcelona  (Genetics  department),  Associated  researcher at the Zoology Department at the University of Oxford. Co-Founder and former director of the Oxford Martin School Institute of Nanomedicine at the University of Oxford. Co-Founder of dNANO. LTD. UK

Selected publications

pH-Dependent Formation of Oriented Zinc Oxide Nanostructures in the Presence of Tannic Acid.
NA Che Lah, A Kamaruzaman, S Trigueros
Nanomaterials 11 (34), 2021


Synthesis, Characterisation and Cytotoxicity of Gold Nanowires for Ultra-Sensitive Biosensor Development.
Nurul Akmal Che Lah, Robert Gray, Sonia Trigueros
BMC, Nov 2020


Nano-scale gene delivery systems: current technology, obstacles, and future directions.
A Garcia-Guerra, TL Dunwell, S Trigueros.
Current medicinal chemistry 25 (21), 2448-2464. 2018


Synthesis and modelling of the mechanical properties of Ag, Au and Cu nanowires.
Nurul Akmal Che Lah and Sonia Trigueros.
Science and Technology of Advanced Materials, 20 (1) 225-261, 2019


Nanoscale Metal Particles as Nanocarriers in Targeted Drug Delivery System
Nurul A C Lah, Mahendran Samykano1 and Sonia Trigueros.
Journal of NanoMedicine Research. 4,  (2) 2016


Mapping nanomechanical properties of live cells using multi-harmonic atomic force microscopy.
Trigueros,A. Raman, A. Cartagena, A. P. Z. Stevenson, M. Susilo, E. Nauman and S. Antoranz Contera These authors contributed equally to this work: A. Raman & S. Trigueros
Nature Nanotechnology  6, (12) 809-814, 2011

All publications

pH-Dependent Formation of Oriented Zinc Oxide Nanostructures in the Presence of Tannic Acid.
NA Che Lah, A Kamaruzaman, S Trigueros
Nanomaterials 11 (34), 2021


Synthesis, Characterisation and Cytotoxicity of Gold Nanowires for Ultra-Sensitive Biosensor Development
Nurul Akmal Che Lah, Robert Gray, Sonia Trigueros
BMC, Nov 2020


In Vitro Gene Delivery in Retinal Pigment Epithelium Cells by Plasmid DNA-Wrapped Gold Nanoparticles.
S Trigueros, EB Domènech, V Toulis, G Marfany
Genes 10 (4) 289, 2019 (Corresponding Author)


Synthesis and Modelling of Mechanical properties of AG, Au and Cu Nanowires
Nurul Akmal Che Lah, and Sonia Trigueros.
STAM 20 (1), 225-261, 2019


Nano-gene-delivery: overcoming one of the major challenges in gene therapy
S Trigueros . Research in Medical and Engineering Sciences 6 (2), 2018 ISSN: 2576-8816


Analysis of Surface alignment of SWCNTs-DNA based Nanobiosensors
S Civit, and S Trigueros.
Research in Medical and Engineering Sciences 6 (5), 2018.


Nano-scale gene delivery systems: Current Technology, obstacles and future directions.
Antonio Garcia, Thomas Dunwell and Sonia Trigueros.
Current Medicinal Chemistry 25(21), 2448-2464. 2018


Nanoscale Metal Particles as Nanocarriers in Targeted Drug Delivery System.
Nurul A C Lah, Mahendran Samykano1 and Sonia Trigueros
Journal of NanoMedicine Research. 4 (2), 2016


Characterization of the RstB2 protein, the DNA binding protein of CTXΦ phage from Vibrio cholerae,
Alina Falero, Sonia Trigueros and Rafael Fando.
Virus Genes 48 (03), 2014.


SpoIIIE mechanism of directional translocation involves target search coupled to sequence-dependent motor stimulation.
Diego I Cattoni, Osvaldo Chara, Cédric Godefroy, Emmanuel Margeat, Sonia Trigueros, Pierre-Emmanuel Milhiet, Marcelo Nöllmann
EMBO Reports14 (5), 473-479, 2013.


SpoIIIe Mechanism of Directional Translocation Involves Target Search Coupled to Allosteric Motor Activation.
DI Cattoni, O Chara, C Godefroy, E Margeat, S Trigueros, P-E Milhiet, M Nollmann.
Biophysical Journal 104, 2013


Estudio de la unión de la proteína pVvgjo del bacteriófago VGJO de V. Cholerae a ADN de cadena simple en ambiente salino
A Falero-Morejón, S Trigueros-Soler, R Fando-Calzada
Revista CENIC. Ciencias Biológicas 43 (1), 41-44, 2012


Three strategies to stabilise nearly monodispersed silver nanoparticles in aqueous solution.
AP Stevenson, D Blanco Bea, S Civit, S Antoranz Contera, A Iglesias Cerveto, S Trigueros.
Nanoscale Res Lett 7 (1) 151-160, 2012


Mapping nanomechanical properties of live cells using multi-harmonic atomic force microscopy.
S. Trigueros, A. Raman, A. Cartagena, A. P. Z. Stevenson, M. Susilo, E. Nauman and S. Antoranz Contera These authors contributed equally to this work: A. Raman & S. Trigueros
Nature Nanotechnology 6, (12) 809-814, 2011


Characterization of pVVGJΦ, the single-stranded DNA binding protein of the phage VGJΦ of Vibrio cholerae.
Alina Falero, Andy Caballero, Sonia Trigueros, M. Cuevas and Rafael Fando.
Biochimica et biophysica acta. 1814 (9), 1107-12. 2011


Mwr Xer site-specific recombination is hypersensitive to DNA supercoiling
Sonia Trigueros*, Tung Tran, Nohemy Sorto, Jason Newmark, Sean D. Colloms, David J. Sherratt and Marcelo E. Tolmasky
Nucleic Acids Research, 37 (11) 2009. *Corresponding Author.


Role of replicative transposons in plasmids’ host range expansion: Implications in dissemination of antibiotic resistance.
DB Buii, N Sorto, S Trigueros, JS Newmark, DJ Sherratt, ME Tolmasky
PLASMID. ( 57 ) 231-234, 2007


Production of highly knotted DNA by means of cosmid circularization inside phage capsids.
Sonia Trigueros and Joaquim Roca
BMC Biotechnology 7 (1), 94, 2007.


Differences in resolution of mrw-containing plasmid dimmers mediated by Klebsiella pneumoniae and Escherichia coli XerC recombinases.
Duyen Bui, Judianne Ramiscal, Sonia Trigueros, Jason Newmark, Albert Do, David Sherratt and Marcelo Tolmasky.
Journal of Bacteriology. 188 (8), 2812-2820, 2006.


DNA knots reveal a chiral organization of DNA in phage capsids.
Javier Arsuaga, Mariel Vazquez, Paul Mc Guirk, Sonia Trigueros, De Witt Sumners, and Joaquim Roca.
Proc. Natl. Acad. Sci. (PNAS) 102 (26) 9165-9169, 2005.


Asymmetric removal of supercoils suggests how topoisomerase II simplifies DNA topology.
Sonia Trigueros, Javier Salceda, Ignacio Bermudez, Xavier Fernandez and Joaquim Roca.
Journal Molecular Biology. 335 (3), 723-31, 2004. Code A. ISSN: 00222836 Area: Molecular Biology Q1
I.F: 4.33 Cited 63.


Cloning, functional analysis and post-transcriptional regulation of a type II DNA Topoisomerase from Leishmania infantum. A new potential target for anti-parasite drugs.
Tobias Hanke, Maria J.Ramiro, Sonia Trigueros, Joaquim Roca and Vicente Larraga.
Nucleic Acids Research. 31 (16), 4917-4928, 2003


A GyrB-GyrA fusion protein expressed in yeast cells is able to remove DNA supercoils but cannot substitute eukaryotic topoisomerase II.
Sonia Trigueros and Joaquim Roca.
Genes to Cells 7 (3), 249-257, 2002. I.F: 2.85. ISNN: 13652443,13569597. Area: Genetics Q1 Cited 15


Failure to relax negative supercoiling of DNA is a primary cause of mitotic Hyper-recombination in topoisomerase-deficient yeast cells.
Sonia Trigueros and Joaquim Roca.
J. Biol. Chem. 277, 37207-37211 (2002).


Knotting probability of DNA molecules confined in restricted volumes: DNA knotting in Phage capsids.
Javier Arsuaga, Mariel Vazquez, Sonia Trigueros, De Witt Sumners, and Joaquim Roca
Proc. Natl. Acad. Sci. USA 99, 5373-5377 (2002).


Circular minichromosomes become highly recombinogenic in topoisomerase-deficient yeast cells.
Sonia Trigueros and Joaquim Roca
J. Biol. Chem. 276, 2243-2249, 2001


Novel display of knotted DNA molecules by two-dimensional gel electrophoresis.
Sonia Trigueros, Javier Arsuaga, Maria E. Vazquez, De Witt Sumners and Joaquim Roca
Nucleic. Acids. Res. 29, (13) 2001

Project funding

Ongoing Projects


Reference: IDX  

Title: Nanotechnology for Infectious diseases

Total awarded € 1.5M 01/10/2020-31/09/2023

R&D project funded by dNANO. Ltd


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