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Lab presentation

The construction and maintenance of the brain and spinal cord is an extremely complex multi-step process by which diversity is generated at all organizational levels.

At the organ level, the relatively simple pseudostratified neuroepithelia need to bend, contract and grow to adapt their form to the functional requirements of the brain domains. At the cellular level, upstream genetic networks bifurcate into downstream sub-networks controlling the proliferative expansion of neural progenitor cells, and their differentiation into a wide variety of neuronal subtypes, in order to build functional circuits.

In the laboratory we address fundamental questions related to the basic principles regulating the shape and growth of the brain and the spinal cord, as well as the mechanisms generating neuron diversity in the developing organ, in health and disease. To that aim, we take advantage of technological developments including advanced microscopy and quantitative imaging that, together with gene editing, allowed following cell and tissue behavior in vivo to an unprecedented level of detail, to model the formation of the human brain and spinal cord in the embryo, as well as their developmental disorders.

Projects

GROWTH OF THE CNS AND ASSOCIATED PRIMARY MICROCEPHALIES

Our aim is to study the control of cell numbers and organ size at birth, as a model to study primary microcephalies. Tight control of the balance between self-expanding symmetric and self-renewing asymmetric neural progenitor divisions is crucial to control the number of cells in the developing nervous system and brain size at birth, and thus to prevent primary microcephalies.

We demonstrated that Sonic hedgehog (Shh) and BMP signalling are required for the expansion of the pool of progenitors by maintaining symmetric divisions. By combining high resolution imaging, and data from transcriptomics and functional genetics, we aim to describe the mechanisms downstream growth factor activities that regulate neural stem cell maintenance.

MORPHOGENESIS OF THE SPINAL CORD ANS ASSOCIATED NEURAL TUBE DEFECTS

Our aim is to study the generation of the Secondary Neural Tube, as a model to study closed spina bifida. Development of the posterior spinal cord involves the elongation and cavitation of the tail bud in a poorly understood process called secondary neurulation.

Importantly, faulty SN is the cause of closed spina bifida. We are combining live imaging and data from transcriptomics and functional genetics, to unveil the gene regulatory networks and tissue dynamics of secondary neural tube formation.

THE DYNAMICS OF NEURAL CREST CELLS AND ASSOCIATED NEUROBLASTOMA

Our aim is to study the dynamics of neural crest cells as a multipotent stem cell-like population that originate from the dorsal spinal cord. Neural crest cells differentiate into a wide range of cell types including the sensory and sympathetic ganglia of the peripheral nervous system, and genetic lesions in these cells generate Neuroblastoma.

We have identified a collection of neural crest specific genes which are common in high risk Neuroblastomas and we are currently investigating the function of these genes in normal and pathological neural crest development. This project is currently being financed by AECC

Research Lines:

  • Morphogenesis of the spinal cord and related NTDs:
    Our aims is to study the generation of the Secondary Neural Tube, as a model to study closed spina bifida. Development of the posterior spinal cord involves the elongation and cavitation of the tail bud in a poorly understood process called secondary neurulation. Importantly, faulty SN is the cause of closed spina bifida. We are combining live imaging and data from transcriptomics and functional genetics, to unveil the gene regulatory networks and tissue dynamics of secondary neural tube formation and to generate computational models with predictive capabilities.
  • Growth of the CNS and associated primary microcephalies (MCPH):
    Our aim is to study the control of cell numbers and organ size at birth, as a model to study primary microcephalies. Tight control of the balance between self-expanding symmetric and self-renewing asymmetric neural progenitor divisions is crucial to control the number of cells in the developing nervous system and brain size at birth, and thus to prevent primary microcephalies. We recently demonstrated that Sonic hedgehog (Shh) and BMP signalling are required for the expansion of the pool of progenitors by maintaining symmetric divisions. We are now combining high resolution imaging and data from transcriptomics and functional genetics, to describe the mechanisms downstream these growth factors that regulate neural stem cell maintenance.
  • The dynamics of neural crest cells and associated Neuroblastomas:
    Our aim is to study the dynamics of neural crest cells as a multipotent stem cell-like population that originate from the dorsal spinal cord. Neural crest cells differentiate into a wide range of cell types including the sensory and sympathetic ganglia of the peripheral nervous system, and genetic lesions in these cells generate Neuroblastoma. We have identified a collection of neural crest specific genes which are common in high risk Neuroblastomas and we are currently investigating the function of these genes in normal and pathological neural crest development. This project is currently being financed by AECC.

Lab people

Principal investigator

Elisa Martí is the head of the “Development of the Spinal Cord in health and disease”
group at the Molecular Biology Institute of Barcelona (IBMB-CSIC). She initiated her
carrier in the field of Developmental Neurobiology as a doctorate student at the Royal
Postgraduate Medical School (RPMS), London University and the University of La
Laguna, Spain, were she set the grounds to identify patterns, conserved along evolution,
for the generation of cell diversity in the developing Spinal Cord. During her postdoctoral training at Harvard University, she established the role of Sonic Hedgehog in the generation of cell diversity in the developing nervous system.

After a second postdoctoral period at the Instituto Cajal, CSIC, Madrid, she established her independent research group in Barcelona (IBMB-CSIC) in 2001, were she is currently a CSIC Research Professor.

She has reconciled the research activity with that of scientific management at the IBMB
where she has been deputy director (2006-2009) and (2011-2014), at ANEP where she
was deputy of Neurobiology and Development (Fundamental and Systems Biology,
BFS 2015-2018) and as Scientific Advisory Board member at ITB_ULL, Tenerife
(2018-), and with the publishing editorial where she is member of the Editorial Board of
Developmental Neurobiology (2011-)

Past students

Selected publications

Selected Publications (las 10 years)Neural Development Group (MARTI)


Elena Gonzalez-Gobartt, José Blanco-Ameijeiras, Susana Usieto, Guillaume Allio, Bertrand Bénazérafand Elisa Martí(2020) Cell intercalation driven by SMAD3 underlies secondary neural tube formation (DEVELOPMENTAL-CELL-D-20-00136, under revision) https://elifesciences.org/articles/37267


MurielleSaade, Diego S Ferrero, José Blanco-Ameijeiras, Elena Gonzalez-Gobartt, Victor M Ruiz-Arroyo, Elena Martínez-Sáez, Santiago Ramón y Cajal, Nuria Verdaguer and Elisa Martí(2020) Multimerization of Zika Virus-NS5 causes a ciliopathy and forcesprematureneurogenesis.(CELL-STEM-CELL-D-20-00214, under Revision) http://www.nature.com/ncb/journal/v19/n5/abs/ncb3512.html


Murielle Saade, Jose Blanco-Ameijeiras, Elena Gonzalez-Gobartt, and Elisa Martí (2018) A centrosomal view of CNS growth Development 145: dev170613 doi: 10.1242/dev.170613 http://dev.biologists.org/content/143/12/2194.long


Gwenvael Le Dréau, René Escalona, Raquel Fueyo, Antonio Herrera, Juan D Martínez, Susana Usieto, Anghara Menendez, Sebastián Pons, Marian A Martinez-Balbas, and Elisa Marti (2018)E proteins sharpen neurogenesis by modulating proneuralbHLH transcription factors activity in an E-box-dependent manner. ElifeAug 10;7. pii: e37267. doi: 10.7554/eLife.37267http://www.sciencedirect.com/science/article/pii/S2211124716305113


Murielle Saade, Elena Gonzalez-Gobartt, Rene Escalona, Susana Usieto and Elisa Martí (2017) Shh-mediated centrosomal recruitment of PKA promotes symmetric proliferative neuroepithelial cell division. Nature Cell Biology 19, 493–503 (2017) doi:10.1038/ncb3512https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4776218/pdf/fncel-10-00047.pdf


M Angeles Rabadán, Antonio Herrera, Lucia Fanlo, Susana Usieto, Carlos Carmona-Fontaine, Elias H. Barriga, Roberto Mayor, Sebastián Ponsand Elisa Martí (2016) Delamination of neural crest cells requires transient and reversible Wnt inhibition mediated by DACT1/2. Development 143(12):2194-205. http://www.ncbi.nlm.nih.gov/pubmed/24942669


Gwenvael Le Dréau, Murielle Saade, Irene Gutierrez-Vallejo and Elisa Martí (2014) The strength of SMAD1/5 activity determines stem cell fate in the developing spinal cord . J Cell Biol. 204 (4) 591-605) doi: 10.1083/jcb.201307031


Murielle Saade, Irene Gutierrez, Gwenvael Le Dreau, M Angeles Rabadán, David G. Miguez, Javier Buceta and Elisa Martí(2013) Sonic hedgehog signaling switches the mode of division in the developing nervous system. Cell Reports 4(3):492-503. doi: 10.1016/j.celrep.2013.06.038. http://www.ncbi.nlm.nih.gov/pubmed/24105267


Gwenvael Le Dréau, Lidia Garcia-Campmany, Angeles Rabadán, Tiago Ferronha, Samuel Tozer, James Briscoe and Elisa Martí(2012) Canonical BMP7 activity is required for the generation of discrete neuronal populations in the dorsal spinal cord. Development139(2):259-68 (2012) doi:10.1242/dev.074948

All publications

All publications (last 10 years) Neural development group


Elena Gonzalez-Gobartt, José Blanco-Ameijeiras, Susana Usieto, Guillaume Allio, Bertrand Bénazérafand Elisa Martí(2020) Cell intercalation driven by SMAD3 underlies secondary neural tube formation (DEVELOPMENTAL-CELL-D-20-00136, under revision) https://elifesciences.org/articles/37267


MurielleSaade, Diego S Ferrero, José Blanco-Ameijeiras, Elena Gonzalez-Gobartt, Victor M Ruiz-Arroyo, Elena Martínez-Sáez, Santiago Ramón y Cajal, Nuria Verdaguer and Elisa Martí(2020) Multimerization of Zika Virus-NS5 causes a ciliopathy and forcesprematureneurogenesis.(CELL-STEM-CELL-D-20-00214, under Revision) bioRxiv 719625; doi: https://doi.org/10.1101/719625


Sonia Najas, Isabel Pijuan, Anna Esteve-Codina, Susana Usieto, Juan D. Martinez, An Zwijsen, Mariona L. Arbonés, Elisa Martí, Gwenvael Le Dréau (2020) A SMAD1/5-YAP signaling module drives radial glial cell expansion and growth of the developing cerebral cortex. Development (in press; MS ID#: DEVELOP/2019/187005)
bioRxiv 558486; doi: https://doi.org/10.1101/558486


Elena Gonzalez-Gobartt, Guillaume Allio, Bertrand Bénazérafand Elisa Martí(2020) In vivo analysis of the Mesenchymal-to-Epithelial transition during chick secondary neurulation. Methods in Molec Biology (in press, ISBN 978-1-0716-0778-7).


Elena Garreta, Patricia Prado, Carolina Tarantino, Roger Oria, Lucia Fanlo, Elisa Martí,DobrynaZalvidea, Xavier Trepat, Pere Roca-Cusachs, AleixGavaldà-Navarro, Luca Cozzuto, Josep Maria Campistol, Juan Carlos Izpisúa Belmonte, Carmen Hurtado del Pozo, Nuria Montserrat (2019) Fine tuning the extracellular environment accelerates the derivation of kidney organoids from human pluripotent stem cells. Nature MaterialsApr;18(4):397-405. doi: 10.1038/s41563-019-0287-6. https://www.nature.com/articles/s41563-019-0287-6


Murielle Saade, Jose Blanco-Ameijeiras, Elena Gonzalez-Gobartt, and Elisa Martí (2018) A centrosomal view of CNS growth Development 145: dev170613 doi: 10.1242/dev.170613 http://dev.biologists.org/content/145/21/dev170613


Gwenvael Le Dréau, René Escalona, Raquel Fueyo, Antonio Herrera, Juan D Martínez, Susana Usieto, Anghara Menendez, Sebastián Pons, Marian A Martinez-Balbas, and Elisa Marti (2018)E proteins sharpen neurogenesis by modulating proneuralbHLH transcription factors activity in an E-box-dependent manner. Elife. 2018 Aug 10;7. pii: e37267. doi: 10.7554/eLife.37267https://elifesciences.org/articles/37267
eLife Digest https://doi.org/10.7554/eLife.37267.002


Kim Dale and Elisa Martí(2017) Introduction to the special section of YDBIO on:
Spinal cord a model to understand CNS development and regeneration. Dev Biol. 2017 Dec 1;432(1):1-2. doi: 10.1016/j.ydbio.2017.10.005. Epub 2017 Oct 13
http://www.sciencedirect.com/science/article/pii/S0012160617307170?via%3Dihub
cover caption http://www.sciencedirect.com/journal/developmental-biology/vol/432/issue/1


DemianBurguera , Yamile Marquez , Claudia Racioppi , Jon Permanyer , Antonio Torres, Rosaria Esposito, Beatriz Albuixech , Lucía Fanlo , Yleniad’Agostino , Enrique Navas-Perez , Ana RiesgY, Claudia Cuomo , Giovanna Benvenuto, Lionel A. Christiaen, Elisa Martí, Salvatore D’Aniello, AntoniettaSpagnuolo, Filomena Ristoratore, MariaInaArnone, Jordi Garcia-Fernàndez, Manuel Irimia (2017) Evolutionaryrecruitment of flexible Esrp-dependentsplicingprogramsintodiverseembryonicmorphogeneticprocesses. Nat Commun. 2017 Nov 27;8(1):1799. doi: 10.1038/s41467-017-01961-y.https://www.nature.com/articles/s41467-017-01961-y


Murielle Saade, Elena Gonzalez-Gobartt, Rene Escalona, Susana Usieto and Elisa Martí (2017) Shh-mediated centrosomal recruitment of PKA promotes symmetric proliferative neuroepithelial cell division. Nature Cell Biology 19, 493–503 (2017) doi:10.1038/ncb3512
http://www.nature.com/ncb/journal/v19/n5/abs/ncb3512.html


M Angeles Rabadán, Antonio Herrera, Lucia Fanlo, Susana Usieto, Carlos Carmona-Fontaine, Elias H. Barriga, Roberto Mayor, Sebastián Ponsand Elisa Martí (2016) Delamination of neural crest cells requires transient and reversible Wnt inhibition mediated by DACT1/2 2 Development 143(12):2194-205. doi: 10.1242/dev.134981. doi: 10.1242/dev.134981.
http://dev.biologists.org/content/143/12/2194.long


Jo Richardson, Anton Gauert, Luis Briones Montecinos, LucíaFanloEscudero, AlhashemZainalabdeen, Elisa Martí, Alexandre Kabla, Steffen Härtel and Claudia Linker (2016) Leader cells define directionality of trunk, but not cranial, neural crest migration. Cell Reports15(9):2076-88. doi: 10.1016/j.celrep.2016.04.067
http://www.sciencedirect.com/science/article/pii/S2211124716305113


Antonio Herrera, Murielle Saade, Anghara Menendez,Elisa Marti and Sebastian Pons(2014) Pre-neoplastic growth caused by sustained Wnt/β-Catenin depends on the localization and activation of aPKC at the apical pole of neuroepithelial cells. Nat Commun 5:4168. doi: 10.1038/ncomms5168.
http://www.ncbi.nlm.nih.gov/pubmed/24942669


Gwenvael Le Dréau, Murielle Saade, Irene Gutierrez-Vallejo and Elisa Martí (2014) The strength of SMAD1/5 activity determines stem cell fate in the developing spinal cord . J Cell Biol. 204 (4) 591-605) doi: 10.1083/jcb.201307031
http://jcb.rupress.org/content/204/4/591.long
Cover picture http://jcb.rupress.org/content/204/4.cover.pdf
Highlighted in JCB, “Career guidance for stem cells” J Cell Biol 2014 204:463. doi:10.1083/jcb.2044if http://jcb.rupress.org/content/204/4/591.abstract


David G. Míguez, Estel Gil-Guiñón, Sebastián Pons and Elisa Martí (2013) Smad2 and Smad3 cooperate and antagonize simultaneously in vertebrate neurogenesisJ Cell Sci. 126(Pt 23):5335-43. doi: 10.1242/jcs.130435.
http://jcs.biologists.org/content/126/23/5335.long


Murielle Saade, Irene Gutierrez, Gwenvael Le Dreau, M Angeles Rabadán, David G. Miguez, Javier Buceta and Elisa Martí(2013) Sonic hedgehog signaling switches the mode of division in the developing nervous system. Cell Reports 4(3):492-503. doi: 10.1016/j.celrep.2013.06.038.
Highlighted in F1000 http://f1000.com/prime/718050366#recommendations-content
http://www.ncbi.nlm.nih.gov/pubmed/23891002


M. Angeles Rabadán, Susana Usieto, CinziaLavarino and Elisa Martí (2013) Identification of a Putative Transcriptome Signature Common to Neuroblastoma and Neural Crest Cells. Dev Neurobiol.Nov;73(11):815-27. doi: 10.1002/dneu.22099. http://onlinelibrary.wiley.com/doi/10.1002/dneu.22099/abstract;jsessionid=5D1D0E90AF9919FF4E333FDB32EE26DB.f01t04 http://www.ncbi.nlm.nih.gov/pubmed/20516201


Gwenvael Le Dréau and Elisa Martí (2013) The multiple activities of BMPs during spinal cord developmentCell Mol Life Sci. 70(22):4293-305. doi: 10.1007/s00018-013-1354-9.
https://link.springer.com/article/10.1007%2Fs00018-013-1354-9


Samuel Tozer, Gwenvael Le Dréau, Elisa Martí and James Briscoe (2013) Temporal control of BMP signalling determines neuronal subtype identity in the dorsal neural tube. Development 140(7):1467-74. doi: 10.1242/dev.090118 http://dev.biologists.org/content/140/7/1467.long
Highlighted in Development (2013) 140(7). http://dev.biologists.org/content/140/7/e705


Tiago Ferronha, M Angeles Rabadán, Estel Gil-Guiñón, GwenvaelLeDreau, Carmen deTorres and Elisa Martí (2013) LMO4 is an essential cofactor in the Snail2-mediated epithelial-to-mesenchymal transition of neuroblastoma and neural crest cells. Journal of Neuroscience 33(7):2794-2806; doi:10.1523/JNEUROSCI.4062-12.2013 http://www.jneurosci.org/content/33/7/2773.long


Gwenvael Le Dreau, and Elisa Martí.(2012) Dorsal-Ventral Patterning of the Neural Tube: A tale of three signals. Dev Neurobiol. 72(12):1471-81 (2012) doi: 10.1002/dneu.22015.
http://onlinelibrary.wiley.com/doi/10.1002/dneu.22015/abstract http://www.jneurosci.org/content/33/7/2773.long


Gwenvael Le Dréau, Lidia Garcia-Campmany, Angeles Rabadán, Tiago Ferronha, Samuel Tozer, James Briscoe and Elisa Martí(2012) Canonical BMP7 activity is required for the generation of discrete neuronal populations in the dorsal spinal cord. Development139(2):259-68 (2012) doi:10.1242/dev.074948
http://dev.biologists.org/content/139/2/259.long
Cover Picture http://dev.biologists.org/content/139/2.cover-expansionhttp://www.jneurosci.org/content/33/7/2773.long


Angeles Rabadán, Jordi Cayuso, Gwenvael Le Dreau, Catarina Cruz, Mercedes Barzi, Sebastián Pons, James Briscoe and Elisa Martí (2012) Jagged2 controls the switch between motor neuron and oligodendrocyte generation in the spinal cord. Cell Death and Differentiation 19(2):209-19 http://www.jneurosci.org/content/33/7/2773.long


Catarina Cruz, Vanessa Ribes, Jordi Cayuso, Eva Kutejova, Dominic Norris, Jonathan Stevens, Nicola Powles-Glover, Megan Davey, Ken Blight, Fiona Bangs, Anita Mynett, Elizabeth Hirst, Steven L. Brody, Elisa Martí and James Briscoe (2010) FoxJ1 is required for neural tube morphogenesis and modifies the response of cells to Shh signalling. Development137:4271-4282
Highlighted inDevelopment137:e2402 “Shh signalling out-Foxed by cilia” http://dev.biologists.org/content/137/24/e2402.full http://www.jneurosci.org/content/33/7/2773.long


NaiaraAkizu, ConchiEstarás, Laura Guerrero, Elisa Martíand Marian A. Martínez-Balbás (2010) H3K27me3 regulates BMP activity in developing spinal cord. Development 137:2915-2925
http://dev.biologists.org/content/137/17/2915.long
Highlighted inDevelopment 137:e1702 “Spinal cord development BuMPs into epigenetics” http://dev.biologists.org/content/137/17/e1702.full http://www.jneurosci.org/content/33/7/2773.long


Bart Lesage, Irene Gutierrez, Elisa Marti and CayetanoGonzaleZ (2010) Neural stem cells: The need for a proper orientation Current Opinion in Genetics & Development 20:1–5 (2010)
http://www.sciencedirect.com/science/article/pii/S0959437X10000778?via%3Dihub


Vanessa Ribes, NikosBalaskas, NoriakiSasai, Eric Dessaud, Catarina Cruz, JordiCayuso, Elisa Martiand James Briscoe (2010) Distinct Sonic Hedgehog signaling dynamics specify floor plate and ventral neuronal progenitors in the vertebrate neural tube. Genes & Development24, 1186-1200 (2010) http://dev.biologists.org/content/137/24/4271.longhttp://www.jneurosci.org/content/33/7/2773.long


Renaud Geslain, Teresa Bori-Sanz, LaiaCubells, Roberto Álvarez-Medina, David Rossell, Elisa Martí and LluísRibas de Pouplana (2010). The endoplasmic reticulum is the first proteome quality checkpoint.Nucleic Acids Res. Mar 1; 38(5): (2010)
https://academic.oup.com/nar/article/38/5/e30/3112494


Fausto Ulloa and Elisa Martí. Wnt Won the War: antagonistic role of Wnt over Shh controls dorso-ventral patterning of the vertebrate neural tube (2010). Developmental Dynamics Jan; 239(1):69-76 (2010) doi: 10.1002/dvdy.22058. Review
http://onlinelibrary.wiley.com/doi/10.1002/dvdy.22058/abstract

Project funding

PARTICIPATION IN RESEARCH PROJECTS

PROJECT TITLE: UNDERSTANDING THE MOLECULAR MECHANISMS REGULATING EMBRYONIC GROWTH OF THE CENTRAL NERVOUS SYSTEM
FINANCIAL ENTITY: PID2019-104134GB-I00
RESEARCH CENTRES: Instituto de Biología Molecular de Barcelona (CSIC)
LENGHT FROM: DEL 01/01/2020 – 31/12/2022
AMOUNT GRANTED: ? €
PRINCIPAL INVESTIGATOR: Elisa Martí Gorostiza


PROJECT TITLE: DE L’ESTRUCTURA ALS MECANISMES PELS QUALS EL VIRUS ZIKA PROVOCA NEUROPATIES CONGÉNITES
FINANCIAL ENTITY: MaratoTV3_2018
RESEARCH CENTRES: Instituto de Biología Molecular de Barcelona
LENGHT FROM: 01/01/2019-310/12/2022
AMOUNT GRANTED 200.000€
PRINCIPAL INVESTIGATOR: Nuria Verdaguez (co-IP Elisa Martí Gorostiza)


PROJECT TITLE: “REDEVNEURAL3.0: AN INTEGRATING APPROACH TO UNDERSTANDING THE LOGIC OF NEURAL DEVELOPMENT “
FINANCIAL ENTITY RED2018-102553-T
RESEARCH CENTRES: CBMSO, CNB, IN-CSIC; UPF, CRG
LENGHT FROM: 2019-2022
AMOUNT GRANTED: 32.000€
PRINCIPAL INVESTIGATOR- COORDINATOR: Paola Bovolenta
PRINCIPAL INVESTIGATOR-SUBPROJECT: Elisa Martí Gorostiza


PROJECT TITLE: GENETIC CONTROL OF THE FORMATION AND GROWTH OF THE SPINAL CORD, A MODEL FOR STUDYING NEURODEVELOPMENTAL DISEASE
FINANCIAL ENTITY: BFU2016-77498-P
RESEARCH CENTRES: Instituto de Biología Molecular de Barcelona
LENGHT FROM: 01/01/2017-310/12/2019
AMOUNT GRANTED 300.000€
PRINCIPAL INVESTIGATOR: Elisa Martí Gorostiza


PARTICIPATION IN RESEARCH PROJECTS (EXPIRED last 10 years)

PROJECT TITLE: CARACTERIZACIÓN DEL SISTEMA NXPH/NRXN COMO MARCADOR DE CELULAS MADRE DE NEUROBLASTOMA Y POSIBLE DIANA TERAPEUTICA”
FINANCIAL ENTITY: AECC CI2016
RESEARCH CENTRES: Instituto de Biología Molecular de Barcelona
LENGHT FROM: 01/09/2016 – 30/09/2019
AMOUNT GRANTED: 150.000 €
PRINCIPAL INVESTIGATOR: Elisa Martí Gorostiza


PROJECT TITLE: “REDEVNEURAL: UN ENFOQUE INTEGRADOR PARA ENTENDER LA LOGICA DEL DESARROLLO NEURAL”
FINANCIAL ENTITY BFU2016-81887-REDT
RESEARCH CENTRES: CBMSO, CNB, IN-CSIC; UPF, CRG
LENGHT FROM: 2017-2019
AMOUNT GRANTED: 28.000 €
PRINCIPAL INVESTIGATOR- COORDINATOR: Paola Bovolenta
PRINCIPAL INVESTIGATOR-SUBPROJECT: Elisa Martí Gorostiza


PROJECT TITLE: DESARROLLO DE LA MEDULA ESPINAL, UN MODELO PARA ESTUDIAR FORMACION DE ORGANOS, BIOLOGIA DE CELULAS MADRE Y TRANSICION EPITELIO MESENQUIMA
FINANCIAL ENTITY: BFU2013-46477-P
RESEARCH CENTRES: Instituto de Biología Molecular de Barcelona (CSIC)
LENGHT FROM: DEL 01/01/2014 – 31/12/2016
AMOUNT GRANTED: 370.000 €
PRINCIPAL INVESTIGATOR: Elisa Martí Gorostiza


PROJECT TITLE: SENYALITZACIO CEL.LULAR EN DESENVOLUPAMENT NORMAL I PATOLÒGIC DEL SISTEMA NERVIOS
FINANCIAL ENTITY Generalitat de Cataluña 2014 GRC 00161
RESEARCH CENTRES Instituto de Biología Molecular de Barcelona (CSIC)
LENGHT FROM: 2014-2016
PRINCIPAL INVESTIGATOR: Elisa Martí Gorostiza


PROJECT TITLE: GENERANDO DIVERSIDAD NEURAL
FINANCIAL ENTITY BFU2014-55738-REDT
RESEARCH CENTRES : CBMSO, CNB, IN-CSIC; UPF, CRG
LENGHT FROM: 2014-2016
AMOUNT GRANTED: 32.000 €
PRINCIPAL INVESTIGATOR- COORDINATOR: Paola Bovolenta
PRINCIPAL INVESTIGATOR-SUBPROJECT: Elisa Martí Gorostiza


PROJECT TITLE: DESARROLLO TEMPRANO DEL SISTEMA NERVIOSO DE VERTEBRADOS CONTROL GENETICO DE LA IDENTIDAD Y LA MORFOLOGIA CELULAR
FINANCIAL ENTITY: BFU2010-18959
RESEARCH CENTRES: Instituto de Biología Molecular de Barcelona (CSIC)
LENGHT FROM: DEL 01/01/2011 AL 30/06/2014
AMOUNT GRANTED: 390.000
PRINCIPAL INVESTIGATOR: Elisa Martí Gorostiza


PROJECT TITLE: From Genes to Shape: analysis of morphogenesis in Drosophila and vertebrates.
FINANCIAL ENTITY: MEC CONSOLIDER CSD2007-00008
RESEARCH CENTRES Instituto de Biología Molecular de Barcelona (CSIC)
LENGHT FROM 2007-2013
AMOUNT GRANTED to the SubGroup 135,000
PRINCIPAL INVESTIGATOR- COORDINATOR: Gines Morata
PRINCIPAL INVESTIGATOR-SUBPROJECT Elisa Martí Gorostiza


PROJECT TITLE: Nonlinear Mechanisms of Spatial Symmetry Breaking in Living Systems
FINANCIAL ENTITY MARIE CURIE FP7-PEOPLE-2009-RG
RESEARCH CENTRES Instituto de Biología Molecular de Barcelona (CSIC)
LENGHT FROM: 2010-2013
AMOUNT GRANTED: 100,000
PRINCIPAL INVESTIGATOR: Elisa Martí Gorostiza


PROJECT TITLE: Desarrollo temprano del sistema nervioso de vertebrados: control genético del crecimiento, diferenciación y morfología celular en el tubo neural.
FINANCIAL ENTITY: BFU2007-60487/BMC
RESEARCH CENTRES: Instituto de Biología Molecular de Barcelona (CSIC)
LENGHT FROM: Dec/2007 to Dec/2010
AMOUNT GRANTED: 312,000
PRINCIPAL INVESTIGATOR: Elisa Martí Gorostiza


PROJECT TITLE: Desarrollo temprano del sistema nervioso de vertebrados: control genético del crecimiento, diferenciación y morfología celular en el tubo neural.
FINANCIAL ENTITY: BFU2007-60487/BMC
RESEARCH CENTRES: Instituto de Biología Molecular de Barcelona (CSIC)
LENGHT FROM: Dec/2007 to Dec/2010
AMOUNT GRANTED: 312,000
PRINCIPAL INVESTIGATOR: Elisa Martí Gorostiza

Vacancies/Jobs

Post Doctoral Positions are availables. If you are interested please send us your CV and cover letter: Elisa Martí (emgbmc@ibmb.csic.es).

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