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Lab presentation

The construction and maintenance of the brain and spinal cord is an extremely complex multi-step process by which diversity is generated at all organizational levels.

At the organ level, the relatively simple pseudostratified neuroepithelia need to bend, contract and grow to adapt their form to the functional requirements of the brain domains. At the cellular level, upstream genetic networks bifurcate into downstream sub-networks controlling the proliferative expansion of neural progenitor cells, and their differentiation into a wide variety of neuronal subtypes, in order to build functional circuits.

In the laboratory we address fundamental questions related to the basic principles regulating the shape and growth of the brain and the spinal cord, as well as the mechanisms generating neuron diversity in the developing organ, in health and disease. To that aim, we take advantage of technological developments including advanced microscopy and quantitative imaging that, together with gene editing, allowed following cell and tissue behavior in vivo to an unprecedented level of detail, to model the formation of the human brain and spinal cord in the embryo, as well as their developmental disorders.

KEY WORD TERMS
Neural development / morphogens in developmental neurobiology / gene regulatory networks for generation of cell diversity / control of cell division in neurogenesis / microcephaly

Projects

GROWTH OF THE CNS AND ASSOCIATED PRIMARY MICROCEPHALIES
(Lead by Elisa Marti)

Our aim is to study the control of cell numbers and organ size at birth, as a model to study primary microcephalies. Tight control of the balance between self-expanding symmetric and self-renewing asymmetric neural progenitor divisions is crucial to control the number of cells in the developing nervous system and brain size at birth, and thus to prevent primary microcephalies.

We demonstrated that Sonic hedgehog (Shh) and BMP signalling are required for the expansion of the pool of progenitors by maintaining symmetric divisions. By combining high resolution imaging, and data from transcriptomics and functional genetics, we aim to describe the mechanisms downstream growth factor activities that regulate neural stem cell maintenance.

growth-of-the-cns and-associated-primary-microcephalies

MORPHOGENESIS OF THE SPINAL CORD AND ASSOCIATED NEURAL TUBE DEFECTS
(Lead by Elisa Marti)

Our aim is to study the generation of the Secondary Neural Tube, as a model to study closed spina bifida. Development of the posterior spinal cord involves the elongation and cavitation of the tail bud in a poorly understood process called secondary neurulation.

Importantly, faulty SN is the cause of closed spina bifida. We are combining live imaging and data from transcriptomics and functional genetics, to unveil the gene regulatory networks and tissue dynamics of secondary neural tube formation.

Portada Thesis

THE DYNAMICS OF NEURAL CREST CELLS AND ASSOCIATED NEUROBLASTOMA
(Lead by Elisa Marti)

Our aim is to study the dynamics of neural crest cells as a multipotent stem cell-like population that originate from the dorsal spinal cord. Neural crest cells differentiate into a wide range of cell types including the sensory and sympathetic ganglia of the peripheral nervous system, and genetic lesions in these cells generate Neuroblastoma.

We have identified a collection of neural crest specific genes which are common in high risk Neuroblastomas and we are currently investigating the function of these genes in normal and pathological neural crest development. This project is currently being financed by AECC.

the-dynamics-of-neural-crest-cells-and-associated-neuroblastoma

THE CENTROSOME/CILIA AXIS IN CNS DEVELOPMENT, EVOLUTION AND DISEASE
(Lead by Murielle Saade)

Our aim is to elucidate the molecular and cellular mechanisms underlying the evolutionary expansion of the developing CNS, specifically the increase in the number of neural precursor cells (NPCs) generated during human embryonic development. Given the recent emergence of the centrosome/cilia axis as a central hub in neurogenesis, we aim at identifying how these organelles control some of these key species-specific features of human CNS and how they relate to human evolution and could be affected in particular neurodevelopmental disorders (NDDs) associated to brain size determination, with a particular emphasis on translating basic research into the identification of molecular targets of human diseases. Our primary tools include the most in vivo dynamic system we can get our hands; the embryonic chick neural tube as well as innovative models of organoids from human pluripotent stem cells, that recapitulate species-specific features of CNS.

cover-2_the centrosome_cilia

Lab people

Senior Principal Investigator

Elisa Martí is a Research Professor at IBMB_CSIC. She has a long standing interest in Developmental Neurobiology, with the particular aim of understanding the formation of the Spinal Cord. She initiated her carrier in the field of Developmental Neurobiology as a doctorate student at the Royal Postgraduate Medical School (RPMS), London University and the University of La Laguna, Spain, were she set the grounds to identify patterns, conserved along evolution, for the generation of cell diversity in the developing Spinal Cord. During her postdoctoral training at Harvard University, she established the morphogenetic role of Sonic Hedgehog (Shh) in the generation of cell diversity in the developing Spinal Cord. These studies provided the foundations to establish her independent research group in Barcelona (IBMB-CSIC) in 2001. Her laboratory is internationally renowned for the work in genetic networks and cellular events that regulate Neural Development. She is particularly recognized for her extensive characterization of the Sonic Hedgehog pathway in neural development, but her research work has also extended to other signalling pathways (Wnt, BMP, TGFb).

She has contributed to scientific management at the IBMB as deputy director (2006-2009) and (2011-2014), and at the Spanish National Agency (AEI) as deputy in Neurobiology and Development (Fundamental and Systems Biology, BFS 2015-2018). She is a member of the Editorial Board of Developmental Neurobiology, and Frontiers in Cell and Developmental Biology.

Junior Principal Investigator

Murielle Saade is a Ramon y Cajal Research Investigator at IBMB. Her fascination to understand embryonic development started early in her scientific career and exponentially grow during her training in 4 different internationally recognized institutions from 4 different countries. After a BSc training at the University of Saint-Joseph-USJ (Lebanon), she moved to University of Aix-Marseille II (France), to carry out her Master and PhD studies under the supervision of Dr. Catherine Nguyen, to study embryonic thymus development and the generation of a correct and functional immune system. After her PhD, she joined the IBMB as a postdoctoral scientist, where she made seminal discoveries in elucidating the roles of the centrosome/ciliary axis in neurogenesis in health and disease.

In 2020, she started her career as a young PI, with the goal to elucidate the molecular and cellular mechanisms underlying the evolutionary human brain expansion. She seeks to understand human neurodevelopmental disorders  such as  microcephaly by studying the roles of centrosomes and primary cilia in cell division and tissue growth.

Past students

Selected publications

Elena Gonzalez-Gobartt, José Blanco-Ameijeiras, Susana Usieto, Guillaume Allio, Bertrand Bénazéraf and Elisa Martí (2021) Cell intercalation driven by SMAD3 underlies secondary neural tube formation Developmental Cell 56, 1147–1163 April 19, 2021 10.1016/j.devcel.2021.03.023
https://pubmed.ncbi.nlm.nih.gov/33878300/


Murielle Saade, Diego S Ferrero, José Blanco-Ameijeiras, Elena Gonzalez-Gobartt, Victor M Ruiz-Arroyo, Elena Martínez-Sáez, Santiago Ramón y Cajal, Nuria Verdaguer and Elisa Martí (2020) Multimerization of Zika Virus-NS5 causes a ciliopathy and forces premature neurogenesis. Cell Stem Cell 2020 Oct 27;S1934-5909(20)30496-3. doi: 10.1016/j.stem.2020.10.002.
https://pubmed.ncbi.nlm.nih.gov/33147489/
Highlighted in Nature Rev Microbiol https://www.nature.com/articles/s41579-020-00481-9


Murielle Saade, Jose Blanco-Ameijeiras, Elena Gonzalez-Gobartt, and Elisa Martí (2018) A centrosomal view of CNS growth  Development 145: dev170613 doi: 10.1242/dev.170613  http://dev.biologists.org/content/145/21/dev170613


Gwenvael Le Dréau, René Escalona, Raquel Fueyo, Antonio Herrera, Juan D Martínez, Susana Usieto, Anghara Menendez, Sebastián Pons, Marian A Martinez-Balbas, and Elisa Marti (2018)  E proteins sharpen neurogenesis by modulating proneural bHLH transcription factors activity in an E-box-dependent manner. Elife 2018 Aug 10;7. pii: e37267. doi: 10.7554/eLife.37267
https://elifesciences.org/articles/37267
Highlighted in eLife Digest https://doi.org/10.7554/eLife.37267.002


Murielle Saade, Elena Gonzalez-Gobartt, Rene Escalona, Susana Usieto and Elisa Martí (2017) Shh-mediated centrosomal recruitment of PKA promotes symmetric proliferative neuroepithelial cell division. Nature Cell Biology 19, 493–503 (2017) doi:10.1038/ncb3512
http://www.nature.com/ncb/journal/v19/n5/abs/ncb3512.html


M Angeles Rabadán, Antonio Herrera, Lucia Fanlo, Susana Usieto, Carlos Carmona-Fontaine, Elias H. Barriga, Roberto Mayor, Sebastián Pons and Elisa Martí (2016) Delamination of neural crest cells requires transient and reversible Wnt inhibition mediated by DACT1/2  2   Development  143(12):2194-205. doi: 10.1242/dev.134981
http://dev.biologists.org/content/143/12/2194.long


Gwenvael Le Dréau, Murielle Saade, Irene Gutierrez-Vallejo and Elisa Martí (2014) The strength of SMAD1/5 activity determines stem cell fate in the developing spinal cord. J Cell Biol.  204 (4) 591-605)  doi: 10.1083/jcb.201307031 Cover picture http://jcb.rupress.org/content/204/4.cover.pdf
Highlighted in JCB, “Career guidance for stem cellsJ Cell Biol 2014 204:463.  doi:10.1083/jcb.2044if http://jcb.rupress.org/content/204/4/591.abstract


Murielle Saade, Irene Gutierrez, Gwenvael Le Dreau, M Angeles Rabadán, David G. Miguez, Javier Buceta and Elisa Martí (2013) Sonic hedgehog signaling switches the mode of division in the developing nervous system. Cell Reports 4(3):492-503. doi: 10.1016/j.celrep.2013.06.038.
http://www.ncbi.nlm.nih.gov/pubmed/23891002
Highlighted in F1000  http://f1000.com/prime/718050366#recommendations-content 


All publications

1._Elena Gonzalez-Gobartt, José Blanco-Ameijeiras, Susana Usieto, Guillaume Allio, Bertrand Bénazéraf and Elisa Martí (2021) Cell intercalation driven by SMAD3 underlies secondary neural tube formation Developmental Cell 56, 1147–1163 April 19, 2021 10.1016/j.devcel.2021.03.023
https://pubmed.ncbi.nlm.nih.gov/33878300/


2._ Murielle Saade, Diego S Ferrero, José Blanco-Ameijeiras, Elena Gonzalez-Gobartt, Victor M Ruiz-Arroyo, Elena Martínez-Sáez, Santiago Ramón y Cajal, Nuria Verdaguer and Elisa Martí (2020) Multimerization of Zika Virus-NS5 causes a ciliopathy and forces premature neurogenesis. Cell Stem Cell 2020 Oct 27;S1934-5909(20)30496-3. doi: 10.1016/j.stem.2020.10.002. https://pubmed.ncbi.nlm.nih.gov/33147489/
Highlighted in Nature Rev Microbiol https://www.nature.com/articles/s41579-020-00481-9


3.- Najas S, Pijuan I, Esteve-Codina A, Usieto S, Martinez JD, Zwijsen A, Arbonés ML, Martí E, Le Dréau G (2020) A SMAD1/5-YAP signalling module drives radial glia self-amplification and growth of the developing cerebral cortex.  Development. 2020 Jul 13;147(13): dev187005. doi: 10.1242/dev.187005 https://dev.biologists.org/content/147/13/dev187005


4.- Gonzalez-Gobartt E, Allio G, Bénazéraf B, Martí Elisa (2020) In Vivo Analysis of the Mesenchymal-to-Epithelial Transition During Chick Secondary Neurulation. Methods Mol Biol. 2021;2179:183-197. doi: 10.1007/978-1-0716-0779-4_16. https://link.springer.com/protocol/10.1007%2F978-1-0716-0779-4_16


5.- Elena Garreta, Patricia Prado, Carolina Tarantino, Roger Oria, Lucia Fanlo, Elisa Martí, Dobryna Zalvidea, Xavier Trepat, Pere Roca-Cusachs, Aleix Gavaldà-Navarro, Luca Cozzuto, Josep Maria Campistol, Juan Carlos Izpisúa Belmonte, Carmen Hurtado del Pozo, Nuria Montserrat (2019) Fine tuning the extracellular environment accelerates the derivation of kidney organoids from human pluripotent stem cells. Nature Materials Apr;18(4):397-405. doi: 10.1038/s41563-019-0287-6. https://www.nature.com/articles/s41563-019-0287-6


6.- Murielle Saade, Jose Blanco-Ameijeiras, Elena Gonzalez-Gobartt, and Elisa Martí (2018) A centrosomal view of CNS growth  Development 145: dev170613 doi: 10.1242/dev.170613  http://dev.biologists.org/content/145/21/dev170613


7.- Gwenvael Le Dréau, René Escalona, Raquel Fueyo, Antonio Herrera, Juan D Martínez, Susana Usieto, Anghara Menendez, Sebastián Pons, Marian A Martinez-Balbas, and Elisa Marti (2018) E proteins sharpen neurogenesis by modulating proneural bHLH transcription factors activity in an E-box-dependent manner. Elife. 2018 Aug 10;7. pii: e37267. doi: 10.7554/eLife.37267
https://elifesciences.org/articles/37267
Highlighted in eLife Digest https://doi.org/10.7554/eLife.37267.002


8.- Kim Dale and Elisa Martí (2017) Introduction to the special section of YDBIO on:
Spinal cord a model to understand CNS development and regeneration. Dev Biol. 2017 Dec 1;432(1):1-2. doi: 10.1016/j.ydbio.2017.10.005. Epub 2017 Oct 13
http://www.sciencedirect.com/science/article/pii/S0012160617307170?via%3Dihub
cover caption http://www.sciencedirect.com/journal/developmental-biology/vol/432/issue/1


9.- Demian Burguera , Yamile Marquez , Claudia Racioppi , Jon Permanyer , Antonio Torres, Rosaria Esposito, Beatriz Albuixech , Lucía Fanlo , Ylenia d’Agostino , Enrique Navas-Perez , Ana RiesgY, Claudia Cuomo , Giovanna Benvenuto, Lionel A. Christiaen, Elisa Martí, Salvatore D’Aniello, Antonietta Spagnuolo, Filomena Ristoratore, Maria Ina Arnone, Jordi Garcia-Fernàndez, Manuel Irimia (2017) Evolutionary recruitment of flexible Esrp-dependent splicing programs into diverse embryonic morphogenetic processes. Nat Commun. 2017 Nov 27;8(1):1799. doi: 10.1038/s41467-017-01961-y. https://www.nature.com/articles/s41467-017-01961-y


10.- Murielle Saade, Elena Gonzalez-Gobartt, Rene Escalona, Susana Usieto and Elisa Martí (2017) Shh-mediated centrosomal recruitment of PKA promotes symmetric proliferative neuroepithelial cell division. Nature Cell Biology 19, 493–503 (2017) doi:10.1038/ncb3512
http://www.nature.com/ncb/journal/v19/n5/abs/ncb3512.html


11.- M Angeles Rabadán, Antonio Herrera, Lucia Fanlo, Susana Usieto, Carlos Carmona-Fontaine, Elias H. Barriga, Roberto Mayor, Sebastián Pons and Elisa Martí (2016) Delamination of neural crest cells requires transient and reversible Wnt inhibition mediated by DACT1/2 Development  143(12):2194-205. doi: 10.1242/dev.134981
http://dev.biologists.org/content/143/12/2194.long


12.- Jo Richardson, Anton Gauert, Luis Briones Montecinos, Lucía Fanlo Escudero, Alhashem Zainalabdeen, Elisa Martí, Alexandre Kabla, Steffen Härtel and Claudia Linker (2016) Leader cells define directionality of trunk, but not cranial, neural crest migration. Cell Reports 15(9):2076-88. doi: 10.1016/j.celrep.2016.04.067
http://www.sciencedirect.com/science/article/pii/S2211124716305113


13.- Serena Mirra, Fausto Ulloa, Irene Gutierrez-Vallejo, Elisa Martì, and Eduardo Soriano (2016) Function of Armcx3 and Arm10/SVH genes in the regulation of progenitor proliferation and neural differentiation in the chicken spinal cord. Front Cell Neurosci  Mar 3;10:47  doi: 10.3389/fncel.2016.00047.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4776218/pdf/fncel-10-00047.pdf


14.- Antonio Herrera, Murielle Saade, Anghara Menendez, Elisa Marti and Sebastian Pons (2014) Pre-neoplastic growth caused by sustained Wnt/β-Catenin depends on the localization and activation of aPKC at the apical pole of neuroepithelial cells. Nat Commun  5:4168. doi: 10.1038/ncomms5168.
http://www.ncbi.nlm.nih.gov/pubmed/24942669


15.- Gwenvael Le Dréau, Murielle Saade, Irene Gutierrez-Vallejo and Elisa Martí (2014) The strength of SMAD1/5 activity determines stem cell fate in the developing spinal cord. J Cell Biol.  204 (4) 591-605)  doi: 10.1083/jcb.201307031
Cover picture http://jcb.rupress.org/content/204/4.cover.pdf
Highlighted in JCB, “Career guidance for stem cellsJ Cell Biol 2014 204:463.  doi:10.1083/jcb.2044if http://jcb.rupress.org/content/204/4/591.abstract


16.- Murielle Saade, Irene Gutierrez, Gwenvael Le Dreau, M Angeles Rabadán, David G. Miguez, Javier Buceta and Elisa Martí (2013) Sonic hedgehog signaling switches the mode of division in the developing nervous system. Cell Reports 4(3):492-503. doi: 10.1016/j.celrep.2013.06.038.
Highlighted in F1000  http://f1000.com/prime/718050366#recommendations-content
http://www.ncbi.nlm.nih.gov/pubmed/23891002


17.- Tiago Ferronha, M Angeles Rabadán, Estel Gil-Guiñón, Gwenvael LeDreau, Carmen deTorres and Elisa Martí  (2013) LMO4 is an essential cofactor in the Snail2-mediated epithelial-to-mesenchymal transition of neuroblastoma and neural crest cells. Journal of Neuroscience 33(7):2794-2806; doi:10.1523/JNEUROSCI.4062-12.2013
http://www.ncbi.nlm.nih.gov/pubmed/23407937


18.- Angeles Rabadán, Jordi Cayuso, Gwenvael Le Dreau, Catarina Cruz, Mercedes Barzi, Sebastián Pons, James Briscoe and Elisa Martí (2012) Jagged2 controls the switch between motor neuron and oligodendrocyte generation in the spinal cord. Cell Death and Differentiation 19(2):209-19 (2012) http://www.ncbi.nlm.nih.gov/pubmed/21720386


19.- Gwenvael Le Dréau, Lidia Garcia-Campmany, Angeles Rabadán, Tiago Ferronha, Samuel Tozer, James Briscoe and Elisa Martí (2012) Canonical BMP7 activity is required for the generation of discrete neuronal populations in the dorsal spinal cord. Development 139(2):259-68 (2012) http://www.ncbi.nlm.nih.gov/pubmed/22159578
Cover Picture http://dev.biologists.org/content/139/2.cover-expansion


20.- Catarina Cruz, Vanessa Ribes, Jordi Cayuso, Eva Kutejova, Dominic Norris, Jonathan Stevens, Nicola Powles-Glover, Megan Davey, Ken Blight, Fiona Bangs, Anita Mynett, Elizabeth Hirst, Steven L. Brody, James Briscoe and Elisa Martí (2010) FoxJ1 is required for neural tube morphogenesis and modifies the response of cells to Shh signalling. Development137:4271-4282
Highlighted inDevelopment137:e2402 “Shh signalling out-Foxed by ciliahttp://dev.biologists.org/content/137/24/e2402.full http://www.jneurosci.org/content/33/7/2773.long


21.– NaiaraAkizu, ConchiEstarás, Laura Guerrero, Marian A. Martínez-Balbás and Elisa Martí (2010) H3K27me3 regulates BMP activity in developing spinal cord. Development 137:2915-2925
http://dev.biologists.org/content/137/17/2915.long
Highlighted inDevelopment 137:e1702 “Spinal cord development BuMPs into epigeneticshttp://dev.biologists.org/content/137/17/e1702.full http://www.jneurosci.org/content/33/7/2773.long


22.– Bart Lesage, Irene Gutierrez, Cayetano Gonzalez and Elisa Marti (2010) Neural stem cells: The need for a proper orientation Current Opinion in Genetics & Development 20:1–5 (2010)
http://www.sciencedirect.com/science/article/pii/S0959437X10000778?via%3Dihub


23.- Vanessa Ribes, NikosBalaskas, NoriakiSasai, Eric Dessaud, Catarina Cruz, JordiCayuso, James Briscoe and Elisa Martí (2010) Distinct Sonic Hedgehog signaling dynamics specify floor plate and ventral neuronal progenitors in the vertebrate neural tube. Genes & Development24, 1186-1200 (2010) http://dev.biologists.org/content/137/24/4271.longhttp://www.jneurosci.org/content/33/7/2773.long


24.– Renaud Geslain, Teresa Bori-Sanz, LaiaCubells, Roberto Álvarez-Medina, David Rossell, LluísRibas de Pouplana and Elisa Martí (2010). The endoplasmic reticulum is the first proteome quality checkpoint.Nucleic Acids Res. Mar 1; 38(5): (2010)
https://academic.oup.com/nar/article/38/5/e30/3112494


25.– Fausto Ulloa and Elisa Martí (2010). Wnt Won the War: antagonistic role of Wnt over Shh controls dorso-ventral patterning of the vertebrate neural tube. Developmental Dynamics Jan; 239(1):69-76 (2010) doi: 10.1002/dvdy.22058. Review
http://onlinelibrary.wiley.com/doi/10.1002/dvdy.22058/abstract


26.- Roberto Alvarez-Medina, Gwenvael Le Dreau, Marian Ros and Elisa Martí (2009) Hedgehog activation is required upstream of Wnt signalling to control neural progenitor proliferation. Development 136(19):3301-3309 (2009)
Highlighted in Development, 136 “Multitasking Wnts in neural development” http://dev.biologists.org/content/136/19/e1904.full


27.- Roberto Alvarez-Medina, Jordi Cayuso, Tadashi Okubo, Shinji Takada and Elisa Martí (2008). Wnt canonical pathway restricts graded Shh/Gli patterning activity through the regulation of Gli3 expression. Development 135, 237-247 (2008) www.ncbi.nlm.nih.gov/pubmed/18057099
Cover Picture http://dev.biologists.org/content/135/2.cover-expansion
Highlighted in Development 2008, 135: 202 “Wnt-Shh neural tube patterning crosstalk” http://dev.biologists.org/content/135/2/e202.full


28.- Lidia García-Campmany and Elisa Martí. The TGFbeta-intracellular effector Smad3 regulates neuronal differentiation and cell fate decisions in the developing spinal cord. Development 134, 65-75 (2007) http://www.ncbi.nlm.nih.gov/pubmed/17138664


29.- Jordi Cayuso, Fausto Ulloa, Barny Cox, James Briscoe, Elisa Martí. The Sonic hedgehog pathway independently controls the patterning, proliferation and survival of neuroepithelial cells by regulating Gli activity. Development 133, 517-528 (2006) http://www.ncbi.nlm.nih.gov/pubmed/16410413

Project funding

PARTICIPATION IN RESEARCH PROJECTS

PROJECT TITLE: UNDERSTAINDING THE MOLECULAR MECHANISMS UNDERLYING ZIKA VIRUS ASSOCIATED NEUROPATHY.
FINANCIAL ENTITY: PID2019-110157RA-I00.
RESEARCH CENTRES: Instituto de Biología Molecular de Barcelona (CSIC)
LENGHT FROM: DEL 06/2020 – 06/2023
AMOUNT GRANTED: 115,000€
PRINCIPAL INVESTIGATOR: Murielle Saade

 

PROJECT TITLE: UNDERSTANDING THE MOLECULAR MECHANISMS REGULATING EMBRYONIC GROWTH OF THE CENTRAL NERVOUS SYSTEM
FINANCIAL ENTITY: PID2019-104134GB-I00
RESEARCH CENTRES: Instituto de Biología Molecular de Barcelona (CSIC)
LENGHT FROM: DEL 01/01/2020 – 31/12/2022
AMOUNT GRANTED: 290.000 €
PRINCIPAL INVESTIGATOR: Elisa Martí Gorostiza

 

PROJECT TITLE: DE L’ESTRUCTURA ALS MECANISMES PELS QUALS EL VIRUS ZIKA PROVOCA NEUROPATIES CONGÉNITES
FINANCIAL ENTITY: MaratoTV3_2018
RESEARCH CENTRES: Instituto de Biología Molecular de Barcelona
LENGHT FROM: 01/01/2019-310/12/2022
AMOUNT GRANTED 200.000€
PRINCIPAL INVESTIGATOR: Nuria Verdaguez (co-IP Elisa Martí Gorostiza)

PROJECT TITLE: “REDEVNEURAL3.0: AN INTEGRATING APPROACH TO UNDERSTANDING THE LOGIC OF NEURAL DEVELOPMENT “
FINANCIAL ENTITY RED2018-102553-T
RESEARCH CENTRES: CBMSO, CNB, IN-CSIC; UPF, CRG
LENGHT FROM: 2019-2022
AMOUNT GRANTED: 32.000€
PRINCIPAL INVESTIGATOR- COORDINATOR: Paola Bovolenta
PRINCIPAL INVESTIGATOR-SUBPROJECT: Elisa Martí Gorostiza

 

PROJECT TITLE: GENETIC CONTROL OF THE FORMATION AND GROWTH OF THE SPINAL CORD, A MODEL FOR STUDYING NEURODEVELOPMENTAL DISEASE
FINANCIAL ENTITY: BFU2016-77498-P
RESEARCH CENTRES: Instituto de Biología Molecular de Barcelona
LENGHT FROM: 01/01/2017-310/12/2019
AMOUNT GRANTED 300.000€
PRINCIPAL INVESTIGATOR: Elisa Martí Gorostiza

PARTICIPATION IN RESEARCH PROJECTS (EXPIRED last 10 years)

PROJECT TITLE: CARACTERIZACIÓN DEL SISTEMA NXPH/NRXN COMO MARCADOR DE CELULAS MADRE DE NEUROBLASTOMA Y POSIBLE DIANA TERAPEUTICA”
FINANCIAL ENTITY: AECC CI2016
RESEARCH CENTRES: Instituto de Biología Molecular de Barcelona
LENGHT FROM: 01/09/2016 – 30/09/2019
AMOUNT GRANTED: 150.000 €
PRINCIPAL INVESTIGATOR: Elisa Martí Gorostiza

PROJECT TITLE: “REDEVNEURAL: UN ENFOQUE INTEGRADOR PARA ENTENDER LA LOGICA DEL DESARROLLO NEURAL”
FINANCIAL ENTITY BFU2016-81887-REDT
RESEARCH CENTRES: CBMSO, CNB, IN-CSIC; UPF, CRG
LENGHT FROM: 2017-2019
AMOUNT GRANTED: 28.000 €
PRINCIPAL INVESTIGATOR- COORDINATOR: Paola Bovolenta
PRINCIPAL INVESTIGATOR-SUBPROJECT: Elisa Martí Gorostiza

PROJECT TITLE: DESARROLLO DE LA MEDULA ESPINAL, UN MODELO PARA ESTUDIAR FORMACION DE ORGANOS, BIOLOGIA DE CELULAS MADRE Y TRANSICION EPITELIO MESENQUIMA
FINANCIAL ENTITY: BFU2013-46477-P
RESEARCH CENTRES: Instituto de Biología Molecular de Barcelona (CSIC)
LENGHT FROM: DEL 01/01/2014 – 31/12/2016
AMOUNT GRANTED: 370.000 €
PRINCIPAL INVESTIGATOR: Elisa Martí Gorostiza

PROJECT TITLE: SENYALITZACIO CEL.LULAR EN DESENVOLUPAMENT NORMAL I PATOLÒGIC DEL SISTEMA NERVIOS
FINANCIAL ENTITY Generalitat de Cataluña 2014 GRC 00161
RESEARCH CENTRES Instituto de Biología Molecular de Barcelona (CSIC)
LENGHT FROM: 2014-2016
PRINCIPAL INVESTIGATOR: Elisa Martí Gorostiza

PROJECT TITLE: GENERANDO DIVERSIDAD NEURAL
FINANCIAL ENTITY BFU2014-55738-REDT
RESEARCH CENTRES : CBMSO, CNB, IN-CSIC; UPF, CRG
LENGHT FROM: 2014-2016
AMOUNT GRANTED: 32.000 €
PRINCIPAL INVESTIGATOR- COORDINATOR: Paola Bovolenta
PRINCIPAL INVESTIGATOR-SUBPROJECT: Elisa Martí Gorostiza

PROJECT TITLE: DESARROLLO TEMPRANO DEL SISTEMA NERVIOSO DE VERTEBRADOS CONTROL GENETICO DE LA IDENTIDAD Y LA MORFOLOGIA CELULAR
FINANCIAL ENTITY: BFU2010-18959
RESEARCH CENTRES: Instituto de Biología Molecular de Barcelona (CSIC)
LENGHT FROM: DEL 01/01/2011 AL 30/06/2014
AMOUNT GRANTED: 390.000
PRINCIPAL INVESTIGATOR: Elisa Martí Gorostiza

PROJECT TITLE: From Genes to Shape: analysis of morphogenesis in Drosophila and vertebrates.
FINANCIAL ENTITY: MEC CONSOLIDER CSD2007-00008
RESEARCH CENTRES Instituto de Biología Molecular de Barcelona (CSIC)
LENGHT FROM 2007-2013
AMOUNT GRANTED to the SubGroup 135,000
PRINCIPAL INVESTIGATOR- COORDINATOR: Gines Morata
PRINCIPAL INVESTIGATOR-SUBPROJECT Elisa Martí Gorostiza

PROJECT TITLE: Nonlinear Mechanisms of Spatial Symmetry Breaking in Living Systems
FINANCIAL ENTITY MARIE CURIE FP7-PEOPLE-2009-RG
RESEARCH CENTRES Instituto de Biología Molecular de Barcelona (CSIC)
LENGHT FROM: 2010-2013
AMOUNT GRANTED: 100,000
PRINCIPAL INVESTIGATOR: Elisa Martí Gorostiza

PROJECT TITLE: Desarrollo temprano del sistema nervioso de vertebrados: control genético del crecimiento, diferenciación y morfología celular en el tubo neural.
FINANCIAL ENTITY: BFU2007-60487/BMC
RESEARCH CENTRES: Instituto de Biología Molecular de Barcelona (CSIC)
LENGHT FROM: Dec/2007 to Dec/2010
AMOUNT GRANTED: 312,000
PRINCIPAL INVESTIGATOR: Elisa Martí Gorostiza

PROJECT TITLE: Desarrollo temprano del sistema nervioso de vertebrados: control genético del crecimiento, diferenciación y morfología celular en el tubo neural.
FINANCIAL ENTITY: BFU2007-60487/BMC
RESEARCH CENTRES: Instituto de Biología Molecular de Barcelona (CSIC)
LENGHT FROM: Dec/2007 to Dec/2010
AMOUNT GRANTED: 312,000
PRINCIPAL INVESTIGATOR: Elisa Martí Gorostiza

Vacancies/Jobs

We’re building a multidisciplinary and enthusiastic group of scientists. We are seeking candidates having a strong background in bioinformatics, or human stem cell reprogramming, and/or developmental biology, to apply for upcoming calls for international postdoctoral fellowships (EMBO and Marie-Curie), and from the Spanish Government (Juan de la Cierva),

Please contact us directly to the following email address:
MURIELLE msabmc@ibmb.csic.es
ELISA emgbmc@ibmb.csic.es
the sooner the better!

We always look for talented undergraduate and graduate students for internships, short-term visits and long-term projects.

Lab corner

Highlighted

Early-Career Researchers in the Time of COVID-19
(DOI: https://doi.org/10.1016/j.stem.2021.01.012).

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