skip to Main Content

Lab presentation

The work of many laboratories has allowed beginning to understand the genetic logic behind development. However, while genes operate in cells and cells are the constituent units that contribute to morphogenesis of organs and of the whole organism, we are still trying to understand how the genetic information that impinges on cell behaviour allows for changes in individual cells that sum up to generate organs. To address this issue, studies need to be done in vivo and in the context of the whole organism.

Thus, we approach this issue by combining the study of three Drosophila morphogenesis models, namely, the embryonic tracheal and gut morphogenesis and the embryonic terminal patterning system. In particular, we focus our study in the role of progenitor cells and epithelial plasticity in these morphogenetic events, with a specital attention on the interaction between different germ layers.

Projects

  • Spatial and temporal triggers taking tracheal adult precursors from quiescence into proliferation
  • Cytoskeleton changes lying behind the transition of tracheal cells from a proliferative to a migratory program
  • Triggers for migration initiation and arrest in the gut morphogenesis, with a particular attention to the interaction between the gut (endoderm) and its surrounding tissue (mesoderm)
  • Interaction between the egg chamber and the early embryo, with special attention on the mechanisms that dictate Torso receptor tyrosine kinase activation

Lab people

Principal investigator

Past students

Sandra Casani

PhD Student

Delia Ricolo

PhD Student

Alessandro Mineo

PhD Student

Selected publications

Collective cell migration and metastases inducedby an epithelial-to-mesenchymal transition in Drosophila intestinal tumors..               

Campbell,K., Rossi, F., Adams, J., Pitsidianaki, I., Barriga, F., Garcia-Gerique, L., Batlle, E., Casanova, J. and Casali, A.Nature Communications (2019)


Holes in the Plasma Membrane Mimic Torso-Like Perforin in Torso Tyrosine Kinase Receptor Activation in the Drosophila Embryo.

Mineo, A., Fuentes, E., Furriols, M. and Casanova, J. Genetics (2018)


Biology, a science of grays.

Casanova, J. Embo Reports (2018)


Differential roles of the Drosophila EMT-inducing transcription factors Snail and Serpent in driving primary tumour growth.

Campbell K, Lebreton G, Franch-Marro X, Casanova J. PLoS Genet. (2018)


A common for framework for EMT and collective cell migration.

Campbell K, Casanova J. Development (2016)


Genetic basis for the evolution of organ morphogenesis: the case of spalt and cut in the development of insect trachea.

de Miguel, C., Linsler,F., Casanova, J.* and Franch-Marro, X.*. Development (2016)


A feedback mechanism converts individual cell features into a supracellular ECM structure in Drosophila trachea.

Öztürk-Çolak, A., Moussian, B., Araújo, S. and Casanova, J. eLife  (2016)


Snoo and Dpp act as spatial and temporal regulators respectively of adult progenitor cells in the Drosophila trachea.

Djabrayan, N. and Casanova, J. PLOS Genetics  (2016)


A role for E-Cadherin in ensuring cohesive migration of a heterogeneous population of non-epithelial cells 

Campbell, K. and Casanova, J. Nature Communications (2015)

Martorell Ò, Barriga FM, Merlos-Suárez A, Stephan-Otto Attolini C, Casanova J, Batlle E, Sancho E and Casali A. Embo Rep (2014)


Specification of Differentiated Adult Progenitors via Inhibition of Endocycle Entry in the Drosophila Trachea.

Djabrayan NJ, Cruz J, de Miguel C, Franch-Marro X and Casanova J. Cell Rep (2014)


Specification of leading and trailing cell features during collective migration in the Drosophila trachea. 

Lebreton G and Casanova J. J Cell Sci,  (2014)


Stemness as a cell default state.

Casanova J. Embo Rep, (2012)

All publications

Collective cell migration and metastases inducedby an epithelial-to-mesenchymal transition in Drosophila intestinal tumors..               

Campbell,K., Rossi, F., Adams, J., Pitsidianaki, I., Barriga, F., Garcia-Gerique, L., Batlle, E., Casanova, J. and Casali, A. Nature Communications (2019)


Up-regulation of TcE93 gene expression acts as the trigger for metamorphosis independently of the threshold size in the beetle Tribolium castaneum.

Chafino,S., Ureña,E., Casanova,J., Casacuberta,E., Franch-Marro,X. and Martín, D. Cell Reports. (2019)


Blimp-1 Mediates Tracheal Lumen Maturation in Drosophila melanogaster.

Öztürk-Çolak,A., Stephan-Otto Attolini, C., Casanova, J*. and Araújo, S.* Genetics (2018)


Holes in the Plasma Membrane Mimic Torso-Like Perforin in Torso Tyrosine Kinase Receptor Activation in the Drosophila Embryo.

Mineo, A., Fuentes, E., Furriols, M. and Casanova, J. Genetics (2018)


Biology, a science of grays.

Casanova, J. Embo Reports (2018)


Differential roles of the Drosophila EMT-inducing transcription factors Snail and Serpent in driving primary tumour growth.

Campbell K, Lebreton G, Franch-Marro X, Casanova J. PLoS Genet. (2018)


GATA factor genes in the Drosophila midgut embryo.

Hernández de Madrid B, Casanova J. PLoS One. (2018)


Transfer of Dorsoventral and Terminal Information from the Ovary to the Embryo by a Common Group of Eggshell Proteins in Drosophila.

Mineo A, Furriols M, Casanova J.  Genetics. (2017)


A common for framework for EMT and collective cell migration.

Campbell K, Casanova J. Development (2016)


Centrosome amplification increases single-cell branching in post-mitotic cells.

Ricolo, D., Deligiannaki, M., Casanova, J. and Araújo, S. Current Biology (2016)


Genetic basis for the evolution of organ morphogenesis: the case of spalt and cut in the development of insect trachea.

de Miguel, C., Linsler,F., Casanova, J.* and Franch-Marro, X.*. Development (2016)


Tumorigenic properties of Drosophila epithelial cells mutant for lethal giant larvae.  

Calleja, M., Morata, G. and Casanova, J. Developmental Dynamics (2016)


A feedback mechanism converts individual cell features into a supracellular ECM structure in Drosophila trachea.

Öztürk-Çolak, A., Moussian, B., Araújo, S. and Casanova, J. eLife  (2016)


Snoo and Dpp act as spatial and temporal regulators respectively of adult progenitor cells in the Drosophila trachea.

Djabrayan, N. and Casanova, J. PLOS Genetics  (2016)


A role for E-Cadherin in ensuring cohesive migration of a heterogeneous population of non-epithelial cells 

Campbell, K. and Casanova, J. Nature Communications (2015)


Ligand-binding and constitutive FGF receptors in single Drosophila tracheal cells. Implications for the role of FGF in collective migration. 

Lebreton, G. Casanova, J. Developmental Dynamics (2015)


Accumulation of the Drosophila Torso-like protein at the blastoderm plasma membrane suggests that it translocates from the eggshell. 

Mineo A, Furriols M and Casanova J. Development (2015)


Germline and somatic vitelline proteins colocalize in aggregates in the follicular epithelium of Drosophila ovaries. 

Furriols M and Casanova J. Fly (2014)


Development: a deep breath for endocrine organ evolution. 

Grillo M, Casanova J and Averof M. Curr Biology (2014)


Iro/IRX transcription factors negatively regulate Dpp/TGF-β pathway activity during intestinal tumorigenesis. 

Martorell Ò, Barriga FM, Merlos-Suárez A, Stephan-Otto Attolini C, Casanova J, Batlle E, Sancho E and Casali A. Embo Rep (2014)


Specification of Differentiated Adult Progenitors via Inhibition of Endocycle Entry in the Drosophila Trachea.

Djabrayan NJ, Cruz J, de Miguel C, Franch-Marro X and Casanova J. Cell Rep (2014)


Conserved mechanisms of tumorigenesis in the Drosophila adult midgut. 

Martorell Ò, Merlos-Suárez A, Campbell K, Barriga FM, Christov CP, Miguel-Aliaga I, Batlle E, Casanova J and Casali A. PLoS One,  (2014)


Specification of leading and trailing cell features during collective migration in the Drosophila trachea.

Lebreton G and Casanova J. J Cell Sci,  (2014)


Deadpan contributes to the robustness of the notch response. 

Babaoğlan AB, Housden BE, Furriols M and Bray SJ. PLoS One, (2013)


The making of a fusion branch in the Drosophila trachea.

Gervais L, Lebreton G and Casanova J. Dev Biol, 362 (2), 187-93 (2012)


Conserved and divergent elements in Torso RTK activation in Drosophila development.

Grillo M, Furriols M, de Miguel C, Franch-Marro X and Casanova J. Sci Rep (2012)


Stemness as a cell default state.

Casanova J. Embo Rep, (2012)


Torso RTK controls Capicua degradation by changing its subcellular localization.

Grimm O, Sanchez Zini V, Kim Y, Casanova J, Shvartsman SY and Wieschaus E. Development,  (2012)


Control of germline torso expression by the BTB/POZ domain protein pipsqueak is required for embryonic terminal patterning in Drosophila.

Grillo M, Furriols M, Casanova J and Luschnig S. Genetics,  (2011)


The Drosophila homologue of SRF acts as a boosting mechanism to sustain FGF-induced terminal branching in the tracheal system.

Gervais L and Casanova J. Development (2011)


Specific GATA factors act as conserved inducers of an endodermal-EMT.

Campbell K, Whissell G, Franch-Marro X, Batlle E and Casanova J. Dev Cell, (2011)


Specification of Differentiated Adult Progenitors via Inhibition of Endocycle

Sequoia establishes tip-cell number in Drosophila trachea by regulating FGF levels.

Araújo SJ and Casanova J. J Cell Sci,  (2011)


Self-induced patched receptor down-regulation modulates cell sensitivity to the hedgehog morphogen gradient.

Casali A. Sci Signal (2010)


A developmentally regulated two-step process generates a noncentrosomal microtubule network in Drosophila tracheal cells. 

Brodu V, Baffet AD, Le Droguen PM, Casanova J* and Guichet A*. Dev Cell,  (2010)


Closca, a new gene required for both Torso RTK activation and vitelline membrane integrity. Germline proteins contribute to Drosophila eggshell composition.

Ventura G, Furriols M, Martín N, Barbosa V and Casanova J. Dev Biol (2010)


Apical constriction and invagination: a very self-reliant couple.

Llimargas M and Casanova J. Dev Biol, (2010)


Mesenchymal-to-epithelial transition of intercalating cells in Drosophila renal tubules depends on polarity cues from epithelial neighbours.

Campbell K, Casanova J and Skaer H. Mech Develop (2010)


In vivo coupling of cell elongation and lumen formation in a single cell. 

Gervais L and Casanova J. Curr Biol, (2010)


A functional antagonism between the pgc germline repressor and torso in the development of somatic cells. 

de Las Heras JM, Martinho RG, Lehmann R and Casanova J. Embo Rep (2009)


Developmental biology. Return to the proliferative pool.

González-Reyes A and Casanova J. Science,  (2008)


Modulation of intracellular trafficking regulates cell intercalation in the Drosophila trachea. 

Shaye DD, Casanova J* and Llimargas M*. Nat Cell Biol (2008)


The emergence of shape: notions from the study of the Drosophila tracheal system.

Casanova J. Embo Rep (2007)


Two distinct but convergent groups of cells trigger Torso receptor tyrosine kinase activation by independently expressing torso-like.

Furriols M, Ventura G and Casanova J. P Natl Acad Sci Usa (2007)


Tramtrack regulates different morphogenetic events during Drosophila tracheal development. 

Araújo SJ, Cela C and Llimargas M. Development (2007)


Spatially distinct downregulation of Capicua repression and tailless activation by the Torso RTK pathway in the Drosophila embryo. 

de las Heras JM and Casanova J. Mech Development (2006)


Association of tracheal placodes with leg primordia in Drosophila and implications for the origin of insect tracheal systems. 

Franch-Marro X, Martín N, Averof M and Casanova J. Development,  (2006)


The RhoGAP crossveinless-c links trachealess and EGFR signaling to cell shape remodeling in Drosophila tracheal invagination.

Brodu V and Casanova J. Gene Development (2006)


Mummy/cystic encodes an enzyme required for chitin and glycan synthesis, involved in trachea, embryonic cuticle and CNS development–analysis of its role in Drosophila tracheal morphogenesis. 

Araújo SJ, Aslam H, Tear G and Casanova J. Dev Biol,  (2005)


Developmental evolution: torso–a story with different ends?. 

Casanova J. Curr Biol  (2005)


Lachesin is a component of a septate junction-based mechanism that controls tube size and epithelial integrity in the Drosophila tracheal system. 

Llimargas M, Strigini M, Katidou M, Karagogeos D and Casanova J. Development,  (2004)


A noncoding RNA is required for the repression of RNApolII-dependent transcription in primordial germ cells.

Martinho RG, Kunwar PS, Casanova J and Lehmann R.  (2004)


Drosophila DDP1, a multi KH-domain protein, contributes to centromeric silencing and chromosome segregation. 

Huertas D, Cortés A, Casanova J and Azorín F. Curr Biol (2004)


In and out of Torso RTK signalling.

Furriols M and Casanova J. EMBO J (2003)

Project funding

 This group is financially supported by:

  • Ministerio de Educación y Ciencia (MEC – Spanish Ministry of  Science & Education).
  • Institute for Research in Biomedicine IRB Barcelona.
  • l’AGAUR- Generalitat de Catalunya.

Vacancies/Jobs

Post Doctoral Positions are availables. If you are interested please send us your CV and cover letter: Jordi Casanova (jcrbmc@ibmb.csic.es).

Lab corner

Date: June 2019_ New Postdoctoral Fellow: Mohamed Abdelsalam.

Contact

Name (*)

Email (*)

Message / Question

I have read and accept the privacy policy (clic here to read)

Back To Top