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Differential roles of the Drosophila EMT-inducing transcription factors Snail and Serpent in driving primary tumour growth

Differential roles of the Drosophila EMT-inducing transcription factors Snail and Serpent in driving primary tumour growth

The group of Jordi Casanova at IBMB has just published their work on two Drosophila transcription factors, the classic EMT inducer Snail and the Drosophila orthologue of hGATAs4/6, Serpent, which drives an alternative mechanism of EMT. Their results provide insight into how transcription factors that induce EMT can also promote primary tumour growth, and how in some cases such as GATA factors a ‘multi hit’ effect may be achieved through the aberrant activation of just a single gene.

Differential roles of the Drosophila EMT-inducing transcription factors Snail and Serpent in driving primary tumour growth - Read More…

A new quinoline BRD4 inhibitor targets a distinct latent HIV-1 reservoir for re-activation from other ‘shock’ drugs

A new quinoline BRD4 inhibitor targets a distinct latent HIV-1 reservoir for re-activation from other ‘shock’ drugs

Researchers of the IBMB have shown that a previously identified Human Immunodeficiency Virus (HIV) latency-reversing agent (MMQO) acts as a bromodomain inhibitor. Despite of very different chemical structures, MMQO mimics the action of JQ1, a well-known bromodomain inhibitor, and binds to the bromodomain and extraterminal domain (BET) family protein BRD4.

A new quinoline BRD4 inhibitor targets a distinct latent HIV-1 reservoir for re-activation from other ‘shock’ drugs - Read More…

Nek9 Phosphorylation Defines a New Role for TPX2 in Eg5-Dependent Centrosome Separation before Nuclear Envelope Breakdown

Nek9 Phosphorylation Defines a New Role for TPX2 in Eg5-Dependent Centrosome Separation before Nuclear Envelope Breakdown

The work, a collaboration between the group of Joan Roig at IBMB and that of Isabelle Vernos at CRG, describes how the Nek9 protein kinase controls the initial phases of cell division and has been published in Current Biology. Incorrect cell division is a frequent cause of aneuploidy (alteration in chromosome number) that can in turn can result in abortions, mental retardation or cancer.

Nek9 Phosphorylation Defines a New Role for TPX2 in Eg5-Dependent Centrosome Separation before Nuclear Envelope Breakdown - Read More…

dBigH1 - the histone H1 variant essential for spermatogenesis

dBigH1 - the histone H1 variant essential for spermatogenesis

Researchers of the IBMB have identified the crucial role of the germline-specific histone dBigH1.

dBigH1 - the histone H1 variant essential for spermatogenesis - Read More…

DNA knots occur in intracellular chromatin

DNA knots occur in intracellular chromatin

Researchers of the IBMB have discovered that steady-state fractions of knotted DNA are common in living cells. The formation and resolution of intracellular DNA knots appears to be mediated by the ubiquitous topoisomerase II activity present throughout eukaryotic chromatin. Analysis of the abundancy and complexity of these DNA knots provides an unique non-invasive approach to infer biophysical and conformational properties of chromatin fibers in vivo.

DNA knots occur in intracellular chromatin - Read More…

Histone H1 depletion triggers an interferon response in cancer cells

Histone H1 depletion triggers an interferon response in cancer cells

Researchers of the IBMB have shown that simultaneous depletion of particular histone H1 variants in human breast cancer cells triggers the cellular interferon response, originally designed to fight against invading pathogen-associated nucleic acids such as DNA or RNA viruses. They have shown that this is due to the derepression of heterochromatic non-coding RNAs such as satellites and endogenous retroviruses, which may be naturally repressed with the participation of particular histone H1 subtypes such as H1.2 and H1.4.

Histone H1 depletion triggers an interferon response in cancer cells - Read More…

The unknown function of the histone H1 protein, discovered

The unknown function of the histone H1 protein, discovered

H1 protein prevents genomic instability and hyperrecombination, which are typical in tumours Scientists at the Barcelona Molecular Biology Institute (IBMB) of the CSIC and at the IRB Barcelona publish their results in Nature Communications

The unknown function of the histone H1 protein, discovered - Read More…

Recruitment of Staufen2 enhances dendritic localization of an intron-containing CaMKIIα mRNA

Recruitment of Staufen2 enhances dendritic localization of an intron-containing CaMKIIα mRNA

Ortiz et al. have found that a subset of the total CaMKIIα mRNA population retains an intron in dendrites. Staufen2 interacts with this intron and enhances the distal dendritic localization of unspliced CaMKIIα mRNA. These findings suggest that intron retention could be a mechanism to modulate dendritic localization of synaptic mRNAs.

Recruitment of Staufen2 enhances dendritic localization of an intron-containing CaMKIIα mRNA - Read More…

Barcelona Conferences on Epigenetics and Cancer (BCEC)

Barcelona Conferences on Epigenetics and Cancer (BCEC)

Members of the IBMB-CSIC organize the international meeting "Epigenetic mechanisms in health and disease", the last of a series of Barcelona Conferences on Epigenetics and Cancer (BCEC), to be held on October 25-26, 2017

Barcelona Conferences on Epigenetics and Cancer (BCEC) - Read More…

Shh-mediated centrosomal recruitment of PKA promotes symmetric proliferative neuroepithelial cell division

Shh-mediated centrosomal recruitment of PKA promotes symmetric proliferative neuroepithelial cell division

The team lead by Elisa Martí has unveiled a mechanism by which growth factors control the mode of cell division. Published in the journal Nature Cell Biology, the study paves the way to understand how the embryonic nervous system grow to acquire the proper size and number of cells, and has clear implications for the pathogenic mechanisms underlying microcephaly.

Shh-mediated centrosomal recruitment of PKA promotes symmetric proliferative neuroepithelial cell division - Read More…

A common framework for EMT and collective cell migration

A common framework for EMT and collective cell migration

Researchers Kyra Campbell and Jordi Casanova at IBMB propose a new concept for the cells displaying arrays of epithelial and mesenchymal features, and migratory behaviours.

A common framework for EMT and collective cell migration - Read More…

Investigadores del CSIC identifican un nuevo mecanismo físico para regular y coordinar movimientos celulares

Investigadores del CSIC identifican un nuevo mecanismo físico para regular y coordinar movimientos celulares

Un estudio dirigido por investigadores del Consejo Superior de Investigaciones Científicas (CSIC) ha identificado un nuevo mecanismo físico que regula y coordina movimientos celulares. El hallazgo podría ayudar a entender algunos procesos dependientes de la migración celular, como la reparación de tejidos y la invasividad celular. Los resultados del trabajo han sido publicados en la revista ‘The EMBO Journal’

Investigadores del CSIC identifican un nuevo mecanismo físico para regular y coordinar movimientos celulares - Read More…

El IBMB recibe 150.000 euros de la AECC para la investigación del cáncer infantil

El IBMB recibe 150.000 euros de la AECC para la investigación del cáncer infantil

El proyecto sobre neuroblastoma de Elisa Martí Gorostiza, investigadora del Instituto de Biología Molecular de Barcelona-CSIC, ha recibido una de las tres ayudas convocadas por la Asociación Española contra el Cáncer (AECC) para proyectos de investigación sobre el cáncer infantil.

El IBMB recibe 150.000 euros de la AECC para la investigación del cáncer infantil - Read More…

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