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DNA knots occur in intracellular chromatin

DNA knots occur in intracellular chromatin

Researchers of the IBMB have discovered that steady-state fractions of knotted DNA are common in living cells. The formation and resolution of intracellular DNA knots appears to be mediated by the ubiquitous topoisomerase II activity present throughout eukaryotic chromatin. Analysis of the abundancy and complexity of these DNA knots provides an unique non-invasive approach to infer biophysical and conformational properties of chromatin fibers in vivo.

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Histone H1 depletion triggers an interferon response in cancer cells

Histone H1 depletion triggers an interferon response in cancer cells

Researchers of the IBMB have shown that simultaneous depletion of particular histone H1 variants in human breast cancer cells triggers the cellular interferon response, originally designed to fight against invading pathogen-associated nucleic acids such as DNA or RNA viruses. They have shown that this is due to the derepression of heterochromatic non-coding RNAs such as satellites and endogenous retroviruses, which may be naturally repressed with the participation of particular histone H1 subtypes such as H1.2 and H1.4.

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The unknown function of the histone H1 protein, discovered

The unknown function of the histone H1 protein, discovered

H1 protein prevents genomic instability and hyperrecombination, which are typical in tumours Scientists at the Barcelona Molecular Biology Institute (IBMB) of the CSIC and at the IRB Barcelona publish their results in Nature Communications

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Recruitment of Staufen2 enhances dendritic localization of an intron-containing CaMKIIα mRNA

Recruitment of Staufen2 enhances dendritic localization of an intron-containing CaMKIIα mRNA

Ortiz et al. have found that a subset of the total CaMKIIα mRNA population retains an intron in dendrites. Staufen2 interacts with this intron and enhances the distal dendritic localization of unspliced CaMKIIα mRNA. These findings suggest that intron retention could be a mechanism to modulate dendritic localization of synaptic mRNAs.

Recruitment of Staufen2 enhances dendritic localization of an intron-containing CaMKIIα mRNA - Read More…

Barcelona Conferences on Epigenetics and Cancer (BCEC)

Barcelona Conferences on Epigenetics and Cancer (BCEC)

Members of the IBMB-CSIC organize the international meeting "Epigenetic mechanisms in health and disease", the last of a series of Barcelona Conferences on Epigenetics and Cancer (BCEC), to be held on October 25-26, 2017

Barcelona Conferences on Epigenetics and Cancer (BCEC) - Read More…

Shh-mediated centrosomal recruitment of PKA promotes symmetric proliferative neuroepithelial cell division

Shh-mediated centrosomal recruitment of PKA promotes symmetric proliferative neuroepithelial cell division

The team lead by Elisa Martí has unveiled a mechanism by which growth factors control the mode of cell division. Published in the journal Nature Cell Biology, the study paves the way to understand how the embryonic nervous system grow to acquire the proper size and number of cells, and has clear implications for the pathogenic mechanisms underlying microcephaly.

Shh-mediated centrosomal recruitment of PKA promotes symmetric proliferative neuroepithelial cell division - Read More…

A common framework for EMT and collective cell migration

A common framework for EMT and collective cell migration

Researchers Kyra Campbell and Jordi Casanova at IBMB propose a new concept for the cells displaying arrays of epithelial and mesenchymal features, and migratory behaviours.

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Investigadores del CSIC identifican un nuevo mecanismo físico para regular y coordinar movimientos celulares

Investigadores del CSIC identifican un nuevo mecanismo físico para regular y coordinar movimientos celulares

Un estudio dirigido por investigadores del Consejo Superior de Investigaciones Científicas (CSIC) ha identificado un nuevo mecanismo físico que regula y coordina movimientos celulares. El hallazgo podría ayudar a entender algunos procesos dependientes de la migración celular, como la reparación de tejidos y la invasividad celular. Los resultados del trabajo han sido publicados en la revista ‘The EMBO Journal’

Investigadores del CSIC identifican un nuevo mecanismo físico para regular y coordinar movimientos celulares - Read More…

El IBMB recibe 150.000 euros de la AECC para la investigación del cáncer infantil

El IBMB recibe 150.000 euros de la AECC para la investigación del cáncer infantil

El proyecto sobre neuroblastoma de Elisa Martí Gorostiza, investigadora del Instituto de Biología Molecular de Barcelona-CSIC, ha recibido una de las tres ayudas convocadas por la Asociación Española contra el Cáncer (AECC) para proyectos de investigación sobre el cáncer infantil.

El IBMB recibe 150.000 euros de la AECC para la investigación del cáncer infantil - Read More…

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