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list of selected publications
  •  Bijlmakers, M.J., Teixeira, J.,M., Boer, R., Mayzel, M., Puig-Sàrries, P., Karlsson, G., Coll, M., Pons, M., Crosas B. (2016) A C2HC zinc finger is essential for the RING-E2 interaction of the ubiquitin ligase RNF125. Sci. Rep. 6:29232

  • Isasa, M., Suñer, C., Díaz, M., Puig-Sàrries, P., Zuin, A., Bichmann, A, Gygi, S,P,, Rebollo, E., Crosas, B. (2016) Cold Temperature Induces the Reprogramming of Proteolytic Pathways in Yeast. J. Biol. Chem. 291(4):1664-75.

  • Zuin, A., Bichmann, A., Isasa, M., Puig-Sàrries, P., Díaz, L.M., Crosas, B. (2015) Rpn10 monoubiquitination orchestrates the association of the ubiquilin-type DSK2 receptor with the proteasome. Biochem. J. 472(3):353-65.

  • Puig-Sàrries, P., Bijlmakers, M.J., Zuin, A., Bichmann, A., Pons, M., Crosas, B. (2015) An intrinsically disordered region of RPN10 plays a key role in restricting ubiquitin chain elongation in RPN10 monoubiquitination. Biochem J. 469(3):455-67

  • Crosas. B. (2014) “Deubiquitinating enzyme inhibitor and their potencial in cance therapy”  Curr. Cancer Drug Targets. 14, 506-516.        

  • Zuin, A., Isasa, M., Crosas, B. (2014) “Ubiquitin signaling: extreme conservation as a source of Diversity” Cells, 3, 690-701.       

  • Isasa, M., Zuin, A., and Crosas, B. (2012) Integration of multiple ubiquitin signals in proteasome regulation”. Methods Mol. Biol. 910, 337-70.

  • Isasa, M., Katz., E.J., Kim, W., Yugo, V., González., S., Kirkpatrick, D.S., Thomson, T.M., Finley., S., Gygi, S.P. and Crosas, B*. (2010) Monoubiquitination of rpn10 regulates substrate recruitment to the proteasome. Molecular Cell, 38(5), 733-745. Cover and preview.
  • Katz., E.J.,  Isasa, M., and Crosas, B* (2010) A new map to understand deubiquitination.  Biochemical Society Transactions, 38(Pt 1): 21-8.
  • Crosas, B.*, Farràs, R., Marfany, G., Rodríguez, M. and Thomson, T.M*. Searching for the boundaries: unlimited expansion of ubiquitin and ubiquitin-like signals in multiple cellular functions (2010) Biochemical Society Transactions, 38(Pt 1): 1-5.
  • Crosas, B., Hanna, J., Kirkpatrick, D.S., Zang, P.,Tone, Y., Hathaway, N.A., Buecker, C., Leggett, D.S., Schmidt, M., King, R.W., Gygi, S.P. and Finley, D.Ubiquitin chains are remodeled at the proteasome by opposing ubiquitin ligase and deubiquitinating activities. Cell 127, 2006, 1401-1413.
  • Hanna, J., Hathaway, N.A., Tone, Y., Crosas, B., Elsasser, S., Kirkpatrick, D.S. Leggett, D.S., Gygi, S.P., King, R.W., and Finley, D. A Deubiquitinating Enzyme Functions Non-catalytically to Inhibit the Proteasome. Cell 2006, 127, 99-111.
  • Shang, F., Deng, G., Liu, Q., Guo, W., Haas, A.L., Crosas, B., Finley, D., Taylor, A. LYS-6-modified ubiquitin inhibits ubiquitin-dependent protein degradation. J. Biol. Chem. 2005, 280, 20365-20374,
  • Schmidt, M., Haas, W., Crosas., B., Santamaria, P.G., Gygi, S.P., Walz. An Finley., D. The HEAT repeat protein Blm10 regulates the yeast proteasome by capping the core particle. Nat. Struct. Mol. Biol. 2005, 12, 294-303.
  • JanseD.M., Crosas, B., Finley, D., Church, G.M. Localization to the Proteasome is Sufficient for Degradation. J. Biol. Chem. 279 (20): 21415-21420, 2004 PDF
  • Crosas, B., Hyndman, D.J., Gallego, O., Martras, S., Parés, X., Flynn, T.G., Farrés, J. Human aldose reductase and human small intestine aldose reductase are efficient retinal reductases: consequences for retinoid metabolism. Biochem. J. 373 (3): 973-979, 2003 PDF
  • Leggett, D.S., Hanna, J., Borodovsky, A., Crosas, B., Schmidt, M., Baker, R.T., Walz, T., Ploegh, H., Finley, D. Multiple associated proteins regulate proteasome structure and function. Mol. Cell 10 (3): 495-507, 2002. PDF
  • Hirschberg, D., Cederlund, E., Crosas, B., Jonsson, A., Tryggvason, S., Farrés, J., Parés, X., Bergman, T., Jornvall, H. N-terminal acetylation in a third protein family of vertebrate alcohol dehydrogenase/retinal reductase found through a 'proteomics' approach in enzyme characterization. Cell. Mol. Life Sci. 58 (9):1323-1326, 2001 PDF
  • Crosas, B., Cederlund, E., Torres, D., Farrés, J., Jörnvall, H. and Parés, X. A vertebrate aldo­keto reductase active with retinoids and ethanol. J. Biol. Chem. 276 (22): 19132-19140, 2001 PDF  
  • Allali-Hassani, A., Crosas, B., , Martínez, S.E., Martras, S., Persson, B., Jörnvall, H., Parés, X. and Farrés, J. Kinetic effects of a single-amino acid mutation in a highly variable loop (residues 114 to 120) of class IV ADH. Chem. Biol. Int. 130-132, 435-444, 2001 PDF
  • Crosas, B., Allali-Hassani, A., Martínez, S.E., Martras, S., Persson, B., Jörnvall, H., Parés, X. and Farrés, J. Molecular basis for differential substrate specificity in class IV alcohol dehydrogenase: A conserved function in retinoid metabolism but not in  ethanol oxidation. J. Biol. Chem. 275 (33): 25180-25187, 2000. PDF
  • Borràs, E., Coutelle, C., Rosell, A., Fernàndez-Muixí, F., Broch, M., Crosas, B., Hjelmqvist, L., Lorenzo, A., Gutiérrez, C., Santos, M., Szczepanek, M., Heilig, M., Quattrocchi, P, Farrés, J., Vidal, F., Richart, C., Mach, T., Bogdal, J., Jörnvall, H., Seitz, H. K., Couzigou, P. and Parés, X. Genetic polymorphisms of alcohol dehydrogenase in Europeans. ADH2 *2 allele decreases the risk for alcoholism and is associated with ADH3 *1. Hepatology 31 (4): 984-989, 2000 PDF
  • Fernández, M.R., Biosca, J.A., Torres, D., Crosas, B. and Parés, X. A double residue substitution in the coenzyme binding site accounts for the different kinetic properties between yeast and human formaldehyde dehydrogenases. J. Biol. Chem. 274 (53): 37869-37875, 1999
  • Peralba, J.M., Cederlund, E., Crosas, B., Moreno, A., Julià, P., Martínez, S.E., Hjelmqvist, L., Persson, B., Farrés, J., Parés, X., Jörnvall, H. Structural and enzymatic properties of a gastric NAPD(H)-dependent and retinal-active alcohol dehydrogenase. J. Biol. Chem. 274 (37): 26021-26026, 1999
  • Peralba, J.M., Crosas, B., Moreno, A., Martínez, S.E., Julià, P., Farrés, J., Parés, X. Amphibian alcohol dehydrogenase. Purification and characterization of classes I and III from Rana perezi. Adv. Exp. Med. Biol. 463: 343-350, 1999.
  • Farrés, J., Moreno, A., Crosas, B., Cederlund, E., Peralba, J.M., Allali-Hassani, A., Hjelmqvist, L., Jörnvall, H., Parés, X. Human and rat class IV alcohol dehydrogenase: correlation of primary structure with enzymatic properties. Adv. Exp. Med. Biol.  372: 331-339, 1994.
  • Farrés, J., Moreno, A., Crosas, B., Peralba, J.M., Allali-Hassani, A., Hjelmqvist, L., Jörnvall, H. and Parés, X. Alcohol dehydrogenase of class IV (ss-ADH) from human stomach. cDNA sequence and structure/function relationship. Eur. J. Biochem. 224, 549-557, 1994.

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