Josep Vilardell: Molecular mechanisms of pre-mRNA splicing
Our research is focused on the molecular mechanisms of the regulation of pre-mRNA splicing, using the budding yeast Saccharomyces cerevisiae and human cells as working systems.
These are our general aims:
- Ribosomal proteins as novel players in tumorigenesis. Antonio de Las Heras-Rubio, Laura Perucho, Rosanna Paciucci, Josep Vilardell, and Matilde Lleonart. Cancer and Metastasis Reviews [Epub ahead of print] (2013) Abstract
- Intronic features that determine the selection of the 3' splice site. Jorge Pérez-Valle and Josep Vilardell. Wiley Interdiscip Rev RNA. Sep-Oct;3(5): 707-717 (2012) Abstract
- RNA secondary structure mediates alternative 3'ss selection in Saccharomyces cerevisiae. Mireya Plass, Carles Codony-Servat, Pedro Gabriel Ferreira, Josep Vilardell, and Eduardo Eyras. RNA Jun;18(6):1103-15 (2012) Abstract
- Regulated pre-mRNA Splicing: The Ghostwriter of the Eukaryotic Genome. Tracy L. Johnson and Josep Vilardell. Biochim. Biophys. Acta 1819: 538–545 (2012) Abstract
- Deciphering 3'ss selection in the yeast genome reveals an RNA thermosensor that mediates alternative splicing. Markus Meyer, Mireya Plass*, Jorge Pérez-Valle*, Eduardo Eyras, and Josep Vilardell. (*Equal contribution). Molecular Cell 43: 1033-1039 (2011) Abstract, (Science Editor's Choice 30 Sept)
- SUS1 introns are required for efficient mRNA nuclear export in yeast. Bernardo Cuenca-Bono&, Varinia García-Molinero&, Pau Pascual-García, Hernan Dopazo, Ana Llopis1, Josep Vilardell*, and Susana Rodríguez-Navarro*. (&: Equal contribution *: corresponding author). Nucleic Acids Research Oct 1;39(19): 8599-611 (2011) Abstract
- RPL30 regulation of splicing reveals distinct roles for Cbp80 in U1 and U2 snRNP cotranscriptional recruitment. Mireia Bragulat, Markus Meyer, Sara Macías, Maria Camats, Mireia Labrador, and Josep Vilardell. RNA Oct;16(10): 2033-2041 (2010) Abstract. Supplemental Material
- The quest for a message: budding yeast, a model organism to study the control of pre-mRNA splicing. Markus Meyer and Josep Vilardell. Briefings in Functional Genomics & Proteomics 8(1):60-7 (2009). Abstract
- L30 binds the nascent RPL30 transcript to repress U2 snRNP recruitment. Macías S, Bragulat M, Tardiff DF, Vilardell J. Molecular Cell 30(6):732-42 (2008). Abstract
- Powering a two-stroke RNA engine. Juan Valcárcel, Josep Vilardell. Nature Structural & Molecular Biology 14(7):574-6 (2007). PubMed
- Repositioning of the reaction intermediate within the catalytic center of the spliceosome. Konarska MM, Vilardell J, Query CC. Molecular Cell 21:543-553 (2006). Abstract
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We are currently seeking highly motivated PhD students and postdocs. Candidates are expected to successfully apply to any suitable fellowship (most Spanish fellowships are competitive and selection is based on the candidate's CV).