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Papagianni, A., Forés, M., Shao, W., He, S., Koenecke, N., Andreu, M.J., Samper, N., Paroush, Z., González-Crespo, S., Zeitlinger, J. and Jiménez, G. (2018) Capicua controls Toll/IL-1 signaling targets independently of RTK regulation. Proc. Natl. Acad. Sci. USA 115, 1807-1812.

Simón-Carrasco, L., Graña, O., Salmón, M., Jacob, H. K. C., Gutierrez, A., Jiménez, G., Drosten, M. and Barbacid, M. (2017) Inactivation of Capicua in adult mice causes T-cell lymphoblastic lymphoma. Genes & Dev. 31, 1456-1468.

Forés, M., Simón-Carrasco, L., Ajuria, L., Samper, N., González-Crespo, S., Drosten, M., Barbacid, M. and Jiménez, G. (2017) A new mode of DNA binding distinguishes Capicua from other HMG-box factors and explains its mutation patterns in cancer. PLOS Genetics 11, e1006622.

Jiménez, G. (ed) (2017) ERK Signaling: Methods and Protocols. Methods in Molecular Biology Series, Springer, New York. 

Forés, M., Papagianni, A., Rodríguez-Muñoz, L. and Jiménez, G. (2017) Using CRISPR-Cas9 to study ERK signaling in Drosophila. Methods Mol. Biol. 1487, 353-365. 

Yang, L., Paul, S., Trieu, K.G., Dent, L.G., Froldi, F., Forés, M., Webster, K., Siegfried, K.R., Kondo, S. Harvey, K., Cheng, L., Jiménez, G., Shvartsman, S. Y. and Veraksa, A. (2016) Minibrain and Wings apart control organ growth and tissue patterning through down-regulation of Capicua. Proc. Natl. Acad. Sci. USA 113, 10583-10588.  

Samee, Md. A. H., Lim, B., Samper, N., Lu, H., Rushlow, C. A., Jiménez, G., Shvartsman, S. Y. and Sinha, S. (2015) A systematic ensemble approach to thermodynamic modeling of gene expression from sequence data. Cell Systems 1, 396-407.   

Jin, Y., Ha, N., Forés, M., Xiang, J., Glaßër, C., Maldera, J., Jiménez, G. and Edgar, B. A. (2015) EGFR/Ras signaling controls Drosophila intestinal stem cell proliferation via Capicua-regulated genes. PLOS Genetics 11, e1005634.    

Forés, M., Ajuria, L., Samper, N., Astigarraga, S., Nieva, C., Grossman, R., González-Crespo, S., Paroush, Z. and Jiménez, G. (2015) Origins of context-dependent gene repression by Capicua. PLOS Genetics 11, e1004902.

Lim, B., Samper, N., Lu, H., Rushlow, C., Jiménez*, G. and Shvartsman*, S. Y. (2013) Kinetics of gene derepression by ERK signaling. Proc. Natl. Acad. Sci. USA 110, 10330-10335. (*Corresponding authors).  

Andreu, M. J., Ajuria, L., Samper, N., González-Pérez, E., Campuzano, S., González-Crespo, S. and Jiménez, G. (2012) EGFR-dependent downregulation of Capicua and the establishment of Drosophila dorsoventral polarity. Fly (Austin) 6, 234-239. 

Helman, A., Lim, B., Andreu, M. J., Kim, Y., Shestkin, T., Lu, H., Jiménez, G., Shvartsman, S. Y. and Paroush, Z. (2012) RTK signaling modulates the Dorsal gradient. Development 139, 3032-3039. 

Andreu, M. J., González-Pérez, E., Ajuria, L., Samper, N., González-Crespo, S., Campuzano, S. and Jiménez, G. (2012) Mirror represses pipe expression in follicle cells to initiate dorsoventral axis formation in DrosophilaDevelopment 139, 1110-1114. 

Jiménez, G. Shvartsman S. and Paroush, Z. (2012) The Capicua repressor - a general sensor of RTK signaling in development and disease. J. Cell Sci. 125, 1383-1391.

Ajuria, L., Nieva, C., Winkler, C., Kuo, D., Samper, N., Andreu, M. J., Helman, A., González-Crespo, S., Paroush, Z., Courey, A. J. and Jiménez, G. (2011) Capicua DNA-binding sites are general response elements for RTK signaling in DrosophilaDevelopment 138, 915-924. 

Kim, Y., Andreu, M. J., Lim, B., Chung, K., Terayama, M., Jiménez, G., Berg, C. A., Lu, H. and Shvartsman, S. Y. (2011) Gene regulation by MAPK substrate competition. Dev. Cell 20, 880-887. 

Helman, A., Cinnamon, E., Mezuman, S., Hayouka, Z., von Ohlen, T., Orian, A., Jiménez, G. and Paroush, Z. (2011) Phosphorylation of Groucho mediates RTK feddback inhibition and prolonged pathway target gene expression. Curr. Biol.21, 1102-1110. 

Kim, Y., Paroush, Z., Nairz, K., Hafen, E., Jiménez*, G. and Shvartsman*, S. Y. (2011) Substrate-dependent control of MAPK phosphorylation in vivo. Mol. Syst. Biol. 7, article number 467.      

Kim, Y., Coppey, M., Grosman, R., Ajuria, L., Jiménez, G., Paroush, Z. and Shvartsman, S. Y. (2010) MAPK substrate competition integrates patterning signals in the Drosophila embryo. Curr. Biol. 20, 446-451. 

Cinnamon, E., Helman, R., Ben-Haroush Schyr, R., Orian, A., Jiménez, G. and Paroush, Z. (2008) Multiple RTK pathways down-regulate Groucho-mediated repression in Drosophila embryogenesis. Development 135, 829-837.

Astigarraga, S., Grossman, R., Díaz-Delfín, J., Caelles, C., Paroush, Z. and Jiménez, G. (2007) A MAPK docking site is critical for downregulation of Capicua by Torso and EGFR RTK signaling. EMBO J26, 668-677.

Morán, E. and Jiménez, G. (2006) The Tailless nuclear receptor acts as a dedicated repressor in the early Drosophila embryo. Mol. Cell. Biol. 26, 3446-3454.

Cinnamon, E., Gur-Wahnon, D., Helman, A., St Johnston, D., Jiménez, G and Paroush, Z. (2004) Capicua integrates input from two maternal systems in Drosophila terminal patterning. EMBO J23, 4571-4582. 

Previous publications

Jiménez, G., González-Reyes, A. and Casanova, J. (2002) Cell surface proteins Nasrat and Polehole stabilize the Torso-like extracellular determinant in Drosophila oogenesis. Genes & Dev. 16, 913-918.

Jiménez, G., Guichet, A., Ephrussi, A. and Casanova, J. (2000) Relief of gene repression by Torso RTK signaling: role of capicua in Drosophila terminal and dorsoventral patterning. Genes & Dev. 14, 224-231.

Eberhard, D., Jiménez, G., Heavy, B. and Busslinger, M. (2000) Transcriptional repression by Pax5 (BSAP) through interaction with corepressors of the Groucho family. EMBO J. 19, 2292-2303.

Jiménez, G., Verrijzer, C.P. and Ish-Horowicz, D. (1999) A conserved motif in Goosecoid mediates Groucho-dependent repression in Drosophilaembryos. Mol. Cell. Biol. 19, 2080-2087. 

Jiménez, G. and Ish-Horowicz, D. (1997) A chimeric Enhancer-of-split transcriptional activator drives neural development and achaete-scute expression. Mol. Cell. Biol. 17, 4355-4362.

Jiménez, G., Paroush, Z. and Ish-Horowicz, D. (1997) Groucho acts as a corepressor for a subset of negative regulators, including Hairy and Engrailed. Genes & Dev. 11, 3072-3082.

Jiménez, G., Pinchin, S.M. and Ish-Horowicz, D. (1996) In vivo interactions of the Drosophila Hairy and Runt transcriptional repressors with target promoters. EMBO J. 15, 7088-7098.

Jiménez, G., Gale, K.B. and Enver, T. (1992) The mouse beta-globin Locus Control Region: hypersensitive sites 3 and 4. Nucleic Acids Res. 20, 5797-5803.

Jiménez, G., Griffiths, S., Ford, A.M., Greaves, M.F. and Enver, T. (1992) Activation of the beta-globin Locus Control Region precedes commitment to the erythroid lineage. Proc. Natl. Acad. Sci. USA 89, 10618-10622.

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