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Jordi Casanova: Cell signalling and morphogenesis

Lab Presentation

The work of many laboratories has allowed beginning to understand the genetic logic behind development. However, while genes operate in cells and cells are the constituent units that contribute to morphogenesis of organs and of the whole organism, we are still trying to understand how the genetic information that impinges on cell behaviour allows for changes in individual cells that sum up to generate organs. To address this issue, studies need to be done in vivo and in the context of the whole organism. Thus, we approach this issue by combining the study of three Drosophila morphogenesis models, namely, the embryonic tracheal and gut morphogenesis and the embryonic terminal patterning system. In particular, we focus our study in the role of progenitor cells and epithelial plasticity in these morphogenetic events, with a specital attention on the interaction between different germ layers.

Jordi Casanova Roca

Principal Investigator

Past students

  • Delia Ricolo

    PhD Student

  • Alessandro Mineo

    PhD Student

  • Campbell,K. and Casanova, J. (2016). A common for framework for EMT and collective cell migration. Development 143, 4291-4300

  • Ricolo, D., Deligiannaki, M., Casanova, J. and Araújo, S. (2016). Centrosome amplification increases single-cell branching in post-mitotic cells. Current Biology.

  •  de Miguel, C., Linsler,F., Casanova, J.* and Franch-Marro, X.* (2016). Genetic basis for the evolution of organ morphogenesis: the case of spalt and cut in the development of insect trachea. Development 143, 3615-3622. (* correspondig autors)

  • Calleja, M., Morata, G. and Casanova, J. (2016). Tumorigenic properties of Drosophila epithelial cells mutant for lethal giant larvae. Developmental Dynamics 245, 834-843.

  • Öztürk-Çolak, A., Moussian, B., Araújo, S. and Casanova, J. (2016). A feedback mechanism converts individual cell features into a supracellular ECM structure in Drosophila trachea. eLife DOI:10.7554/eLife.09373.

  • Djabrayan, N. and Casanova, J. (2016) Snoo and Dpp act as spatial and temporal regulators respectively of adult progenitor cells in the Drosophila trachea. PLOS Genetics | DOI:10.1371/journal.pgen.1005909.

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Post Doctoral Positions are availables

 This group is financially supported by:

  • Ministerio de Educación y Ciencia (MEC - Spanish Ministry of  Science & Education)
  • Institute for Research in Biomedicine IRB Barcelona
  • l'AGAUR- Generalitat de Catalunya

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